RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis
RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis
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DOI：
10.1359/jbmr.060308
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发表时间：
2006-06-01
影响因子：
6.2
通讯作者：
Saeki, Y
中科院分区：
文献类型：
--
作者：
Ishii, M;Iwai, K;Saeki, Y
我们发现，CD 9，四跨膜蛋白超家族蛋白的成员，在一个特定的膜微区，称为“脂筏”，是至关重要的细胞融合过程中，破骨细胞生成激活后的RANK/RANKL系统。
We showed that CD9, a member of tetraspanin superfamily proteins, is expressed in a specific membrane microdomain, called "lipid raft," and is crucial for cell fusion during osteoclastogenesis after activation of the RANK/RANKL system.