Gel wax-based tissue-mimicking phantoms for multispectral photoacoustic imaging.
Gel wax-based tissue-mimicking phantoms for multispectral photoacoustic imaging.
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DOI：
10.1364/boe.9.001151
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发表时间：
2018-03-01
影响因子：
3.4
通讯作者：
Desjardins AE
中科院分区：
文献类型：
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作者：
Maneas E;Xia W;Ogunlade O;Fonseca M;Nikitichev DI;David AL;West SJ;Ourselin S;Hebden JC;Vercauteren T;Desjardins AE
组织模拟体模广泛用于医学成像系统的校准、评估和标准化以及临床培训。对于光声成像，非常需要具有可调光学和声学特性、高稳定性和机械鲁棒性的仿组织材料（TMF）。在这项研究中，凝胶蜡作为TMM，满足这些标准的开发光声成像幻影。减少的散射和光吸收系数独立调谐与添加的二氧化钛和油基油墨。随频率变化的声衰减服从幂律;对于天然凝胶蜡，其变化范围为3 MHz时的0.71 dB/cm至12 MHz时的9.93 dB/cm。所选择的油基油墨，其中具有不同的光学吸收光谱在400至900 nm的范围内，被发现具有良好的光稳定性下的脉冲照明与光声激发光。制作了由不同浓度的炭黑和彩色油墨组成的光学非均匀幻影，并利用光学参量振荡器和平面法布里-珀罗传感器进行了多光谱光声成像。我们得出结论，凝胶蜡是非常适合作为TMM的多光谱光声成像。
Tissue-mimicking phantoms are widely used for the calibration, evaluation and standardisation of medical imaging systems, and for clinical training. For photoacoustic imaging, tissue-mimicking materials (TMMs) that have tuneable optical and acoustic properties, high stability, and mechanical robustness are highly desired. In this study, gel wax is introduced as a TMM that satisfies these criteria for developing photoacoustic imaging phantoms. The reduced scattering and optical absorption coefficients were independently tuned with the addition of TiO2 and oil-based inks. The frequency-dependent acoustic attenuation obeyed a power law; for native gel wax, it varied from 0.71 dB/cm at 3 MHz to 9.93 dB/cm at 12 MHz. The chosen oil-based inks, which have different optical absorption spectra in the range of 400 to 900 nm, were found to have good photostability under pulsed illumination with photoacoustic excitation light. Optically heterogeneous phantoms that comprised of inclusions with different concentrations of carbon black and coloured inks were fabricated, and multispectral photoacoustic imaging was performed with an optical parametric oscillator and a planar Fabry-Pérot sensor. We conclude that gel wax is well suited as a TMM for multispectral photoacoustic imaging.