The Immunoglobulins: New Insights, Implications, and Applications
The Immunoglobulins: New Insights, Implications, and Applications
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免疫球蛋白：新见解、意义和应用
DOI：
10.1146/annurev-animal-021419-083720
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Zhao, Yaofeng
中科院分区：
文献类型：
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作者：
Sun, Yi;Huang, Tian;Zhao, Yaofeng
免疫球蛋白 (Igs) 作为适应性免疫的标志之一，最早在大约 5 亿年前随着有颌脊椎动物的出现而出现。在 Ig 从软骨鱼到哺乳动物的进化史上，有两个事件引人注目：(a) Ig 重链 (IgH) 基因的多样化，产生了与新功能相关的 Ig 同种型或亚类；(b) 遗传和结构策略的多样化，导致了我们今天所知的抗体库的产生。本综述首先概述了迄今为止在有颌脊椎动物中鉴定出的 IgH 同种型，然后重点介绍了对不同脊椎动物物种 Ig 进行比较研究所产生的近期五项新发现的意义或应用。
Immunoglobulins (Igs), as one of the hallmarks of adaptive immunity, first arose approximately 500 million years ago with the emergence of jawed vertebrates. Two events stand out in the evolutionary history of Igs from cartilaginous fish to mammals: (a) the diversification of Ig heavy chain (IgH) genes, resulting in Ig isotypes or subclasses associated with novel functions, and (b) the diversification of genetic and structural strategies, leading to the creation of the antibody repertoire we know today. This review first gives an overview of the IgH isotypes identified in jawed vertebrates to date and then highlights the implications or applications of five new recent discoveries arising from comparative studies of Igs derived from different vertebrate species.