Acute effects of a nucleoside analog dideoxyinosine (DDI) on the pancreas.
Acute effects of a nucleoside analog dideoxyinosine (DDI) on the pancreas.
复制标题
核苷类似物双脱氧肌苷 (DDI) 对胰腺的急性影响。
DOI：
10.1016/0022-4804(92)90262-x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Cameron,JL
中科院分区：
文献类型：
--
作者：
Nordback,IH;Olson,JL;Chaisson,RE;Cameron,JL
二脱氧肌苷(DDI，VIDEX)是最近发展起来的一种核苷类似物，具有抗人类免疫缺陷病毒的活性。接受DDI治疗的艾滋病患者或与艾滋病相关的复合体患者中，有相当数量的人发展为急性胰腺炎。本研究利用间日圆线菌融合犬胰腺制剂，研究DDI对胰腺的急性影响。对照制剂在4小时的灌注期内保持正常。在灌流液中加入12.5mgDDI(约100mol.mol/升)，对制剂没有任何影响。在灌流液中加入62.5mgDDI(约500mol.mol/升)，不会引起大体外观、体重增加或淀粉酶活性的变化。但给药后动脉压和氧耗量均显著下降。经电子显微镜观察，腺泡细胞中的酶原含量也减少。蛋白质分泌暂时增加，可能是由于腺泡细胞排空(分泌增加而没有新的合成)。在第四个灌流小时内，水和碳酸氢盐的分泌量也增加。
Dideoxyinosine (DDI, Videx) is a recently developed nucleoside analog with activity against the human immunodeficiency virus. A significant number of patients with AIDS or AIDS-related complex treated with DDI have developed acute pancreatitis. This study was performed to investigate the acute effects of DDI on the pancreas utilizing an isolatedex vivoperfused canine pancreas preparation. Control preparations remained normal throughout a 4-hr perfusion period. The addition of 12.5 mg of DDI to the perfusate (ca. 100 μmol/liter) did not induce any changes in the preparation. The addition of 62.5 mg of DDI to the perfusate (ca. 500 μmol/liter) did not induce changes in the gross appearance, weight gain, or amylase activity. However, the arterial pressure and the oxygen consumption of the preparation decreased significantly after the administration of DDI. The amount of zymogen in the acinar cells also decreased, as evaluated by electron microscopy. Protein secretion increased temporarily, probably as a result of acinar cell emptying (increased secretion without new synthesis). Water and bicarbonate secretion were also increased during the fourth perfusion hour.