Vitamin D and risk of preeclampsia: A systematic review and meta-analysis
Vitamin D and risk of preeclampsia: A systematic review and meta-analysis
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DOI：
10.7705/biomedica.v38i0.3683
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发表时间：
2018-05-01
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影响因子：
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通讯作者：
Quintero-Lesmes, Doris Cristina
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文献类型：
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作者：
Serrano-Díaz, Norma Cecilia;Gamboa-Delgado, Edna Magaly;Quintero-Lesmes, Doris Cristina
简介：人类维生素 D 水平与多种临床结果的关系日益密切。有大量关于其关联的报道，特别是与产科并发症，包括先兆子痫和妊娠糖尿病。这些结果几乎不一致，并且仍然缺乏高质量的干预研究来证实维生素 D 在这些结果中的作用。目的：回顾关于母体维生素 D 在先兆子痫发生中的作用的现有科学证据。材料和方法：所使用的方法遵循 Cochrane 系统评价指南的建议，以及流行病学观察研究荟萃分析指南 (MOOSE) 的荟萃分析建议。搜索包括观察性研究和对照临床试验。结果：通过 25-羟基维生素 D 测试测得的维生素 D 水平低在妊娠期很常见。这项系统评价和荟萃分析的结果表明，维生素 D 水平与先兆子痫的发生之间存在反比关系。这些研究在设计、人群、地理位置、暴露定义和结果方面存在异质性。我们从这项荟萃分析中排除了随机对照试验。结论：我们发现的负相关表明，维生素 D 水平越高，发生先兆子痫的可能性越小，尽管此类分析中总体测量结果存在异质性。
Introduction: Human vitamin D levels have been increasingly related to a wide range of clinical outcomes. There is a large amount of reports on its associations, especially with obstetric complications, including preeclampsia and gestational diabetes. These results are scarcely consistent and there is still a lack of quality intervention studies to confirm the role of vitamin D in those outcomes.Objective: To review the available scientific evidence on the role of maternal vitamin D in the development of preeclampsia.Materials and methods: The methodology used followed the recommendations of the Cochrane guide for the preparation of systematic reviews, and for metaanalysis, the Guide of the Metaanalysis of Observational Studies in Epidemiology group (MOOSE). The search included both observational studies and controlled clinical trials.Results: Low vitamin D levels, measured by the 25-hydroxyvitamin D test, are common in pregnancy. The results of this systematic review and metaanalysis suggest an inverse ratio between vitamin D levels and the development of preeclampsia. There was heterogeneity among the studies with regard to the design, population, geographic location, definitions of exposure, and the outcome. We excluded randomized controlled trials from this meta-analysis.Conclusion: The inverse association we found suggests that the higher the levels of vitamin D the lesser the probability of developing preeclampsia, in spite of the heterogeneity of the global measurement in this type of analysis.