PROTECTION AGAINST HEPATITIS-B VIRUS-INFECTION BY IMMUNIZATION WITH HEPATITIS-B CORE ANTIGEN
PROTECTION AGAINST HEPATITIS-B VIRUS-INFECTION BY IMMUNIZATION WITH HEPATITIS-B CORE ANTIGEN
复制标题
DOI：
10.1016/0016-5085(85)90148-9
复制
发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
GERETY, RJ
中科院分区：
文献类型：
--
作者：
IWARSON, S;TABOR, E;GERETY, RJ
尽管针对B型肝炎表面抗原的抗体通常提供针对B型肝炎病毒（HBV）感染的保护，但最近的报告表明情况并非总是如此。为了研究对B型肝炎核心抗原的免疫应答在对HBV感染的免疫中的可能作用，用黑猩猩肝脏衍生的或基因克隆的B型肝炎核心抗原免疫黑猩猩，然后用已知的传染性HBV攻击黑猩猩。两个黑猩猩，接受肝衍生的或克隆的肝炎B核心抗原的弗氏佐剂和开发的肝炎B核心抗体和低滴度的肝炎B e抗体，完全保护免受HBV感染后的挑战。相反，另一只接受肝源性B型肝炎核心抗原而无佐剂的黑猩猩，仅在血清中产生了B型肝炎核心抗体，并且在挑战时具有亚临床HBV感染。抗HBV感染的保护作用显然可以通过用佐剂中的B型肝炎核心抗原免疫来诱导，并且在这种情况下，保护作用不仅仅依赖于B型肝炎表面抗体。这一事实对理解HBV注射的生物学和未来B型肝炎疫苗的设计具有重要意义。
Although antibody to the hepatitis B surface antigen usually provides protection against hepatitis B virus (HBV) infection, recent reports indicate that this is not always the case. To study the possible role of immune responses to hepatitis B core antigen in immunity to HBV infection, chimpanzees were immunized with chimpanzee liver-derived or genetically cloned hepatitis B core antigen and later challenged with known infectious HBV. Two chimpanzees, which received liver-derived or cloned hepatitis B core antigen in Freund''s adjuvant and developed hepatitis B core antibody and low-titer hepatitis B e antibody, were completely protected against HBV infection following challenge. In contrast, another chimpanzee, which received liver-derived hepatitis B core antigen without adjuvant, developed hepatitis B core antibody only in serum and had a subclinical HBV infection when challenged. Protection against HBV infection can evidently be induced by immunization with hepatitis B core antigen in adjuvant and that protection, in this case, is not solely dependent on hepatitis B surface antibody. This fact has important implications in understanding the biology of HBV injection and in the design of future hepatitis B vaccines.