Methadone maintenance programs - A two-edged sword?
Methadone maintenance programs - A two-edged sword?
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DOI：
10.1097/00000433-200012000-00012
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发表时间：
2000-12-01
影响因子：
1
通讯作者：
Byard, RW
中科院分区：
文献类型：
--
作者：
Green, H;James, RA;Byard, RW
在1996年7月至1999年6月的3年期间，对南澳大利亚法医科学中心检测到美沙酮的所有尸检进行了回顾性审查。发现美沙酮导致或促成死亡的病例35例（年龄范围14 ~ 54岁；平均31岁；M:F = 3.4:1）。10名受害者参加了美沙酮维持计划，其中4人在登记后一周内死亡。未参加美沙酮维持计划的8名受害者（23%）在使用“转移”美沙酮（即为其他人开的处方）后死亡（年龄范围= 14-34岁；平均= 25岁；M:F = 6.2）。8例中有7例死亡直接归因于美沙酮毒性，7例中发现了其他药物或酒精。预防美沙酮转移引起的持续死亡可以通过只允许每天释放美沙酮，而上瘾者必须在密切监督下服用药物来实现。
Retrospective review was undertaken of all autopsies in which methadone was detected at the Forensic Science Centre, South Australia, during a 3-year period from July 1996 to June 1999. Thirty-five cases were found in which methadone had either caused or contributed to death (age range = 14-54 years; average = 31 years; M:F = 3.4:1). Ten victims were participating in a methadone maintenance program, of whom four died within a week of enrollment. Eight victims (23%) not enrolled in a methadone maintenance program were found who had died after the use of "diverted" methadone (i.e., prescribed for someone else) (age range = 14-34 years; average = 25 years; M:F = 6.2). Deaths were directly attributable to methadone toxicity in seven of the eight cases, with additional drugs or alcohol being found in seven cases. Prevention of ongoing deaths caused by methadone diversion could be achieved by allowing only daily releases of methadone, with the addict having to consume the drug under close supervision.