Correlation between level of (n-3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study
Correlation between level of (n-3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study
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DOI：
10.1016/0005-2760(96)00007-0
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发表时间：
1996-05-20
期刊：
影响因子：
--
通讯作者：
Hoy, CE
中科院分区：
文献类型：
--
作者：
Jensen, MM;Skarsfeldt, T;Hoy, CE
The effects of dietary n - 3 polyunsaturated fatty acids (PUFAs) on major brain phospholipids were examined in the rat throughout four generations. Dietary fats were: a seal oil (22:6(n - 3) located mainly in the sn-1/3-position of the TG); a fish oil (22:6(n - 3) located mainly in the sn-2 position of the TG); or a vegetable oil containing 18:3(n - 3). The effect of the TG structure of the dietary fat and chain length of n - 3 PUFA on assimilation in the brain was compared with chow fed rats. The rats fed marine fats had significantly higher levels of long-chain n - 3 PUFAs in brain PE and PS, compared to the vegetable oil and chow fed rats, but no effects of TG structure of dietary fat were observed. Dietary 18:3(n - 3) raised the amount of 22:6(n - 3) compared to the control group, but not to the levels of the marine groups that received preformed 22:6(n - 3). Fish oil fed rats had higher levels of 20:5(n - 3) and 22:5(n - 3) compared with the seal oil fed rats, whereas 22:6(n - 3) were similar. Only minor changes in PI, PIP, and PIP2 were found. The fourth generation was tested for spatial learning ability in a Morris water maze. The experimental groups had similar learning abilities, which een were increased compared to the control group.
