Place fields of rat hippocampal pyramidal cells and spatial learning in the watermaze
Place fields of rat hippocampal pyramidal cells and spatial learning in the watermaze
复制标题
DOI：
10.1046/j.0953-816x.2001.01487.x
复制
发表时间：
2001-03-01
影响因子：
3.4
通讯作者：
Moser, EI
中科院分区：
文献类型：
--
作者：
Hollup, SA;Molden, S;Moser, EI
为研究空间学习过程中海马神经元的位置相关活动提供背景，我们比较了海马位置细胞在环形水迷宫和类似的陆地任务中的活动。在这两种条件下，复杂的穗细胞有强大的地方相关，和一个显着比例的细胞在相同的位置有地方字段。然而，在潮湿的条件下，现场射击率略高。在一次开放水域任务中也观察到了升高的射击。当平台位置随机变化或根本没有平台时，没有增强。第二，游泳时位置场受到较强的方向性调制。在环形任务中，无论动物是否经过训练找到平台，方向敏感性都出现了。开放式水迷宫中也有定向调制单位，但数量少于走廊。总而言之，这些观察结果表明，在水迷宫中的位置字段在很大程度上是由相同的因素在陆地上控制，尽管在动觉和前庭输入的差异。放电率和方向控制的差异可能取决于任务的几何和认知结构，而不是大鼠移动的媒介。
To provide a background for studying place-related activity in hippocampal neurons during spatial learning, we compared the activity of hippocampal place cells in an annular watermaze and an analogous land-based task. Complex-spike cells had robust place correlates in both conditions, and a significant proportion of the cells had place fields at the same locations. However, the in-field firing rates were slightly higher in the wet condition. Elevated firing was observed also in an open water task. There was no enhancement when the platform location was varied randomly or when there was no platform at all. Second, the place fields were under stronger directional modulation during swimming. In the annular task, directional sensitivity appeared regardless of whether the animals were trained to find a platform or not. There were directionally modulated units also in the open watermaze, but the number was smaller than in the corridor. Altogether, these observations suggest that place fields in the watermaze are largely controlled by the same factors as on dry land, in spite of the differences in kinaesthetic and vestibular input. Differences in firing rate and directional control may depend on the geometric and cognitive structure of the task rather than the medium on which the rats are moving.