Colorectal carcinoma: A retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University
Colorectal carcinoma: A retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University
复制标题
DOI：
10.1007/s10350-007-0248-z
复制
发表时间：
2007-07-01
影响因子：
3.9
通讯作者：
Lebaschi, Amir H.
中科院分区：
文献类型：
--
作者：
Fazeli, Mohhamad S.;Adel, Maryam Ghavami;Lebaschi, Amir H.
结直肠癌是世界上最常见的癌症之一，在伊朗也是如此。在年龄和性别上，癌的亚部位存在差异。本研究的目的是描述结直肠癌的分布在诊断时的年龄，性别和肿瘤的亚部位。这些因素也在诊断时与疾病阶段和肿瘤分化一起进行评估。方法：来自1995年4月至2001年3月期间在癌症研究所和Imam Khomieni医院诊断为结直肠癌的419例未接受筛查的患者的数据用于描述结直肠癌的年龄、性别、肿瘤亚部位和病理学以及诊断时的分期分布。结果：腺癌403例（96.2%）。男性和女性分别占病例的52.4%和47.6%。平均年龄为52.3岁。患者分为两个年龄组（40岁及以下，40岁以上）; 16.4%的患者近端结肠有肿瘤，83.6%的患者远端结肠有肿瘤。大多数患者为II期和III期（分别为48.1%和33.4%）。两个年龄组的肿瘤亚部位分布几乎相同（40岁及以下：近端，18.5%，远端，81.5%; 40岁以上：近端，15.7%，远端，84.3%）。年轻组的大多数患者为III期（45%），老年组为II期（53.2%; P < 0.001）。40岁及以下患者的肿瘤分化比例为：良好，24.4%;中度，53.6%;差，22%; 40岁以上患者的肿瘤分化比例为：良好，41.5%;中度，52.6%;差，5.9%（P < 0.001）。两种性别之间的分期和肿瘤分化没有差异，但大多数近端结肠肿瘤患者为男性（62.5%; P=0.1）。结论：在我们的研究中，大多数结直肠癌发生在远端，因此大多数结直肠癌可以通过直肠乙状结肠镜检查发现。由于年轻患者的病情更严重，因此筛查和“临床怀疑”在年轻患者中的重要性很重要。
PURPOSE: Colorectal carcinoma is one of the most common cancers in the world as well as in Iran. There are differences in subsite of the carcinoma when considering age and gender. This study was designed to describe the distribution of colorectal carcinoma by age at diagnosis, gender, and subsite of the tumor. These factors also are evaluated in conjunction with disease stage and tumor differentiation at the time of diagnosis. METHODS: Data from 419 patients from a population that receives no screening between April 1995 and March 2001 operated on in the Cancer Institute and Imam Khomieni Hospital with a diagnosis of colorectal cancer were used to describe distribution of the colorectal carcinoma by age, gender, tumor subsite and pathology, and stage at diagnosis. RESULTS: There were 403 (96.2 percent) cases of adenocarcinoma. Males and females constituted 52.4 and 47.6 percent of cases, respectively. The mean age was 52.3 years. Patients were divided into two age groups (40 years and younger, and older than 40 years); 16.4 percent of patients had tumors in the proximal colon and 83.6 percent in distal parts. Most patients were Stage II and III (48.1 and 33.4 percent, respectively). Tumor subsite distribution was almost the same between the two age groups (aged 40 years and younger: proximal, 18.5 percent, and distal, 81.5 percent; older than aged 40 years: proximal, 15.7 percent, and distal, 84.3 percent). Most patients in the younger age group were Stage III (45 percent) and in the older age group were Stage II (53.2 percent; P < 0.001). Tumor differentiation proportions in patients aged 40 years and Younger were: good, 24.4 percent; moderate, 53.6 percent; poor, 22 percent; and in patients older than aged 40 years were: good, 41.5 percent; moderate, 52.6 percent; poor, 5.9 percent (P < 0.001). There were no differences in stage and tumor differentiation between two genders, but most of the patients with tumors in proximal colon were males (62.5 percent; P=0.1). CONCLUSIONS: Most of the colorectal carcinomas were in distal parts in our study, so most of these carcinomas can be detected by proctosigmoidoscopy. Because younger patients had more advanced disease, the importance of screening and "clinical suspicion" in the young is important.