A two-step mechanism underlies the planar polarization of regenerating sensory hair cells
A two-step mechanism underlies the planar polarization of regenerating sensory hair cells
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DOI：
10.1073/pnas.0608536103
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发表时间：
2006-12-05
影响因子：
11.1
通讯作者：
Hudspetht, A. J.
中科院分区：
文献类型：
--
作者：
Lopez-Schier, Hernan;Hudspetht, A. J.
平面细胞极性的恢复是感觉器官再生过程中生理恢复的一个重要步骤，但人们对其了解甚少。在斑马鱼侧线研究这一问题时，我们发现毛细胞沿着其祖细胞的受限定位和定向分裂所建立的单轴成对再生。通过分析缺乏平面极性决定因素Vangl2的突变体，我们确定毛细胞的单轴产生及其随后的毛束取向受到不同途径的控制，这些途径的结合奠定了毛细胞在发育和再生过程中取向的建立。这一机制可能代表了在上皮重塑过程中平面细胞极性长期维持的一般原则。
The restoration of planar cell polarity is an essential but poorly understood step toward physiological recovery during sensory-organ regeneration. Investigating this issue in the lateral line of the zebrafish, we found that hair cells regenerate in pairs along a single axis established by the restricted localization and oriented division of their progenitors. By analyzing mutants lacking the planar-polarity determinant Vangl2, we ascertained that the uni-axial production of hair cells and the subsequent orientation of their hair bundles are controlled by distinct pathways, whose combination underlies the establishment of hair-cell orientation during development and regeneration. This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia.