Bridging the Gap between GPCR Activation and Behaviour: Oxytocin and Prolactin Signalling in the Hypothalamus
Bridging the Gap between GPCR Activation and Behaviour: Oxytocin and Prolactin Signalling in the Hypothalamus
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弥合 GPCR 激活与行为之间的差距：下丘脑中的催产素和催乳素信号传导
DOI：
10.1007/s12031-010-9452-8
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发表时间：
2011
影响因子：
3.1
通讯作者：
I. Neumann
中科院分区：
文献类型：
--
作者：
E. V. D. Burg;I. Neumann
大脑的神经肽是重要的神经调节剂，控制行为和生理。它们通过G蛋白偶联受体(GPCR)传递信号，G蛋白偶联受体耦合到复杂的细胞内信号通路。这些信号网络整合了来自多个来源的信息，导致了对环境和内部暗示的适当的生理和行为反应。本文将重点介绍催产素和催乳素在神经内分泌应激反应和焦虑中的调节作用，以及(2)这些神经肽的受体介导的分子机制。除了在释放到血液中时具有显著的生殖功能外，脑后叶催产素还可以降低下丘脑-垂体-肾上腺(HPA)轴的活动以及雄性和雌性大鼠的焦虑相关行为。催产素至少部分地通过与其在下丘脑室旁核的GPCR结合，继而反式激活表皮生长因子受体，继而激活MEK-细胞外信号调节激酶(ERK)MAP激酶通路，从而介导其抗焦虑作用。催乳素通过与其GPCR受体(有短的和长的两种形式)结合，也激活ERK，这对于控制促肾上腺皮质激素释放激素的表达是必要的，促肾上腺皮质激素释放激素是HPA轴的重要调节因子。配基催产素和催乳素也可能招募其他信号通路，但这些通路如何对观察到的行为和生理影响做出贡献仍有待确定。GPCR介导的催产素和催乳素神经元信号转导说明了GPCR激活的对环境和生理需求的适当神经内分泌和行为反应的调节的复杂性。
Neuropeptides of the brain are important neuromodulators, controlling behaviour and physiology. They signal through G protein-coupled receptors (GPCR) that couple to complex intracellular signalling pathways. These signalling networks integrate information from multiple sources, resulting in appropriate physiological and behavioural responses to environmental and internal cues. This paper will focus on the neuropeptides oxytocin and prolactin with respect to (1) the regulation of neuroendocrine stress responses and anxiety, and (2) the receptor-mediated molecular mechanisms underlying these actions of the neuropeptides. Besides its significant reproductive functions when released into the bloodstream, brain oxytocin reduces the activity of the hypothalamo–pituitary–adrenal (HPA) axis as well as anxiety-related behaviour in male and female rats. Oxytocin mediates its anxiolytic effect, at least in part, via binding to its GPCR in the hypothalamic paraventricular nucleus, followed by transactivation of the epidermal growth factor receptor, and subsequent activation of a MEK–extracellular signal-regulated kinase (ERK) MAP kinase pathway. Prolactin, by binding to its GPCR receptors, of which there are short and long forms, also activates ERK, and this is necessary for the control of the expression of corticotrophin-releasing hormone—an important regulator of the HPA axis. Liganded oxytocin and prolactin may also recruit other signalling pathways, but how these pathways contribute to the observed behavioural and physiological effects remains to be established. GPCR-mediated oxytocin and prolactin neuronal signalling are illustrative of the complexity of GPCR-activated regulation of appropriate neuroendocrine and behavioural responses to environmental and physiological demands.
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影响因子：
4.8
作者：
C. Ku;Ansha Qian;Yeshao Wen;Khursheed Anwer;Barbara M. Sanborn
通讯作者：
C. Ku;Ansha Qian;Yeshao Wen;Khursheed Anwer;Barbara M. Sanborn
影响因子：
4.1
作者：
DEVITO, WJ;STONE, S;AVAKIAN, C
通讯作者：
AVAKIAN, C
将催乳素从血液转运至脑脊液的受体介导机制。
影响因子：
4.8
作者：
Walsh,RJ;Slaby,FJ;Posner,BI
通讯作者：
Posner,BI
ERK2 介导催产素刺激的 PGE2 合成。
DOI：
10.1152/ajpendo.1998.274.4.e634
发表时间：
1998
期刊：
The American journal of physiology
影响因子：
--
作者：
Strakova,Z;Copland,JA;Lolait,SJ;Soloff,MS
通讯作者：
Soloff,MS
影响因子：
4.8
作者：
Zhong, M;Yang, M;Sanborn, BM
通讯作者：
Sanborn, BM