MEG and EEG demonstrate similar test-retest reliability of the 40Hz auditory steady-state response.
MEG and EEG demonstrate similar test-retest reliability of the 40Hz auditory steady-state response.
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DOI：
10.1016/j.ijpsycho.2017.01.013
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Rojas DC
中科院分区：
文献类型：
--
作者：
Legget KT;Hild AK;Steinmetz SE;Simon ST;Rojas DC
听觉稳态反应（ASSR）越来越多地被用作神经精神疾病的生物标志物，但需要研究这种测量方法的重测信度。我们以前报告的ASSR的可靠性，测量脑电图（EEG），以40 Hz的调幅白色噪声和点击列车刺激。本研究的目的是（a）评估MEG测量的ASSR的可靠性，40 Hz调幅白色噪声和点击列车刺激，（B）比较MEG和EEG测量ASSR之间的重测信度，这是以前没有调查。此外，通过比较对白色噪声和点击串刺激的响应，评估了刺激参数选择对可靠性的影响。在17名健康成年人中评估了大约间隔一周的重测信度。在每个研究日，参与者在单独的MEG和EEG记录期间完成两个被动听力任务（白色噪声和点击训练刺激）。诱发功率和试验间相位相干性（ITPC）的会话之间的相关性进行了评估后，源空间投影。总体而言，MEG测量的ASSR在会话之间显著相关（p < 0.05，FDR校正），表明可接受的重测信度。结果表明，更大的响应再现性ITPC相比，诱发反应和点击列车相比，白色噪声刺激，但需要进一步的研究。MEG和EEG测量之间的可靠性没有显著差异，表明它们同样可靠。这项工作支持使用ASSR作为生物标志物在临床干预措施的重复测量。
The auditory steady-state response (ASSR) is increasingly being used as a biomarker in neuropsychiatric disorders, but research investigating the test-retest reliability of this measure is needed. We previously reported ASSR reliability, measured by electroencephalography (EEG), to 40 Hz amplitude-modulated white noise and click train stimuli. The purpose of the current study was to (a) assess the reliability of the MEG-measured ASSR to 40 Hz amplitude-modulated white noise and click train stimuli, and (b) compare test-retest reliability between MEG and EEG measures of ASSR, which has not previously been investigated. Additionally, impact of stimulus parameter choice on reliability was assessed, by comparing responses to white noise and click train stimuli. Test-retest reliability, across sessions approximately one week apart, was assessed in 17 healthy adults. On each study day, participants completed two passive listening tasks (white noise and click train stimuli) during separate MEG and EEG recordings. Between-session correlations for evoked power and inter-trial phase coherence (ITPC) were assessed following source-space projection. Overall, the MEG-measured ASSR was significantly correlated between sessions (p < 0.05, FDR corrected), suggesting acceptable test-retest reliability. Results suggest greater response reproducibility for ITPC compared to evoked responses and for click train compared to white noise stimuli, although further study is warranted. No significant differences in reliability were observed between MEG and EEG measures, suggesting they are similarly reliable. This work supports use of the ASSR as a biomarker in clinical interventions with repeated measures.