Beta-arrestins in the context of cardiovascular diseases: Focusing on angiotensin II type 1 receptor (AT1R)
Beta-arrestins in the context of cardiovascular diseases: Focusing on angiotensin II type 1 receptor (AT1R)
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DOI：
10.1016/j.cellsig.2022.110253
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发表时间：
2022-02-01
影响因子：
4.8
通讯作者：
Barreto-Chaves, Maria Luiza
中科院分区：
文献类型：
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作者：
Lino, Caroline Antunes;Barreto-Chaves, Maria Luiza
心血管疾病是全世界死亡的主要原因。肾素-血管紧张素-醛固酮系统是心血管稳态的主要调节剂之一，血管紧张素II 1型受体（AT 1 R）介导由该激素系统的过度活化引起的主要有害作用。β-抑制蛋白是调节G蛋白偶联受体的脱敏和内化的多功能蛋白质。在β-抑制蛋白被发现后，许多研究者都致力于表征和区分这一新的信号通路以用于药物发现。在这里，我们总结了最近的进展，解决β-arrestin信号在心血管系统中，重点是AT 1 R的激活。
Cardiovascular diseases are the leading cause of death worldwide. The renin-angiotensin-aldosterone system is one of the major regulators of cardiovascular homeostasis and the angiotensin II type 1 receptor (AT1R) mediates the main deleterious effects resulting from the hyperactivation of this hormonal system. Beta-arrestins are multifunctional proteins that regulate the desensitization and internalization of G protein-coupled receptors. After the discovery of beta-arrestins, many efforts have been made towards characterizing and distinguishing this new signaling pathway for drug discovery. Here, we summarize recent advances that address the beta-arrestin signaling in the cardiovascular system, focusing on the activation of the AT1R.