Inverted direction of wave propagation (IDWP) in the cochlea
Inverted direction of wave propagation (IDWP) in the cochlea
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DOI：
10.1121/1.2828064
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发表时间：
2008-03-01
影响因子：
2.4
通讯作者：
Nuttall, Alfred L.
中科院分区：
文献类型：
--
作者：
de Boer, Egbert;Zheng, Jiefu;Nuttall, Alfred L.
关于波传播的“经典”观点认为，波可以沿着基底膜的长度在两个方向上传播，并且它们具有相同的性质。最近执行的几个实验的结果[T.Ren，NAT.神经科。2,333-334(2004)和W.X.He，A.L.Nutall，和T.Ren，听到。第228、112-122(2007)号决议]似乎与这一观点相矛盾。在本工作中，测量了豚鼠基底膜(BM)的速度。失真产物(DPS)是通过呈现两个主音产生的，其频率低于进行BM测量的BM位置的特征频率f(0)，具有恒定的频率比率。在每个实验中，主DP的相位被记录为DP频率的函数，频率为2f(1)-f(2)。结果表明，从双音相互作用区向距骨方向传播的DP波不仅是反向传播的，而且是正向传播的。前向波出现的区域范围似乎比经典理论所能解释的要大。这一特性被称为“波传播的反向”。这项研究的结果证实了其他作者的波传播发现。将实验数据与基于同一动物的噪声响应数据的经典耳蜗三维模型的理论预测进行了比较。对这些发现背后可能的物理机制进行了讨论。(C)2008年美国声学学会。
The "classical" view on wave propagation is that propagating waves are possible in both directions along the length of the basilar membrane and that they have identical properties. Results of several recently executed experiments [T. Ren, Nat. Neurosci. 2, 333-334 (2004) and W. X. He, A. L. Nuttall, and T. Ren, Hear. Res., 228, 112-122 (2007)] appear to contradict this view. In the current work measurements were made of the velocity of the guinea-pig basilar membrane (BM). Distortion products (DPs) were produced by presenting two primary tones, with frequencies below the characteristic frequency f(0) of the BM location at which the BM measurements were made, with a constant frequency ratio. In each experiment the phase of the principal DP, with frequency 2f(1) -f(2), was recorded as a function of the DP frequency. The results indicate that the DP wave going from the two-tone interaction region toward the stapes is not everywhere traveling in the reverse direction, but also in the forward direction. The extent of the region in which the forward wave occurs appears larger than is accounted for by classical theory. This property has been termed "inverted direction of wave propagation." The results of this study confirm the wave propagation findings of other authors. The experimental data are compared to theoretical predictions for a classical three-dimensional model of the cochlea that is based on noise-response data of the same animal. Possible physical mechanisms underlying the findings are discussed. (C) 2008 Acoustical Society of America.