Sound Localization of World and Head-Centered Space in Ferrets.
Sound Localization of World and Head-Centered Space in Ferrets.
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DOI：
10.1523/jneurosci.0291-22.2022
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发表时间：
2022-06-01
期刊：
影响因子：
--
通讯作者：
Bizley JK
中科院分区：
文献类型：
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作者：
Town SM;Bizley JK
声音的位置可以在多个坐标系中描述，这些坐标系是相对于我们自己或我们周围的世界定义的。来自动物神经记录的证据指出，大脑中存在以头部为中心和以世界为中心的声音定位表征;然而，目前还不清楚这种神经表征是否与非人类听众的声音定位能力有感知相关性。在这里，我们建立了新的行为测试，以确定坐标系统，雪貂可以本地化的声音。我们发现，雪貂可以学会区分声音位置，这些声音位置固定在以世界为中心的空间或以头部为中心的空间中，在替代坐标系中声音位置的广泛变化中。使用探测声音来评估更广泛的空间听觉概括，我们证明了在头部和以世界为中心的任务中，动物使用听觉空间的连续地图来指导行为。单个动物的单次试验反应提供了足够的信息，我们可以使用特定坐标系中的扬声器位置来模拟声音定位，并准确预测雪貂在保留数据中的行为。我们的研究结果表明，一个动物模型中，神经元被称为调谐到声音的位置在自我中心和allocentric参考框架也可以本地化的声音在多个头部和世界为中心的空间。
The location of sounds can be described in multiple coordinate systems that are defined relative to ourselves, or the world around us. Evidence from neural recordings in animals point towards the existence of both head-centered and world-centered representations of sound location in the brain; however, it is unclear whether such neural representations have perceptual correlates in the sound localization abilities of non-human listeners. Here, we establish novel behavioral tests to determine the coordinate systems in which ferrets can localize sounds. We found that ferrets could learn to discriminate between sound locations that were fixed in either world-centered or head-centered space, across wide variations in sound location in the alternative coordinate system. Using probe sounds to assess broader generalization of spatial hearing, we demonstrated that in both head and world-centered tasks, animals used continuous maps of auditory space to guide behavior. Single trial responses of individual animals were sufficiently informative that we could then model sound localization using speaker position in specific coordinate systems and accurately predict ferrets’ actions in held-out data. Our results indicate that an animal model in which neurons are known to be tuned to sound location in egocentric and allocentric reference frames can also localize sounds in multiple head and world-centered spaces.