A new type of membrane contact in the ER-Golgi system regulates autophagosome biogenesis
A new type of membrane contact in the ER-Golgi system regulates autophagosome biogenesis
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内质网-高尔基体系统中新型膜接触调节自噬体生物发生
DOI：
10.1080/15548627.2021.1972406
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发表时间：
2021-10
期刊：
影响因子：
13.3
通讯作者：
Liang Ge
中科院分区：
文献类型：
--
作者：
Shulin Li;Min Zhang;Liang Ge
双膜自噬体的形成需要内膜系统的膜重组以产生膜前体。ER-高尔基体运输系统已显示为吞噬细胞生长提供膜。尽管如此，ER-高尔基体系统的组成部分如何被重定向到自噬体生物合成仍然不清楚。在这里，我们确定了一种新的类型的膜接触之间形成的ER-高尔基体中间室（ERGIC）和ER出口网站（ERES）下macroautophagy/autophagy-induction条件。ERGIC-ERES接触是通过TMED 9-PREB/SEC 12相互作用建立的，并调节ERGIC-COPII囊泡的生物发生，我们以前发现ERGIC-COPII囊泡充当LC 3脂化和自噬体形成的膜模板。
ABSTRACT Formation of the double-membrane autophagosome requires membrane reorganization of the endomembrane system to generate membrane precursors. The ER-Golgi trafficking system has been shown to provide membranes for phagophore growth. Nonetheless, how the components of the ER-Golgi system are redirected toward autophagosome biogenesis remains unclear. Here, we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment (ERGIC) and the ER-exit sites (ERES) under macroautophagy/autophagy-induction conditions. The ERGIC-ERES contact is established by the TMED9-PREB/SEC12 interaction and regulates the biogenesis of the ERGIC-COPII vesicles, which we found previously act as a membrane template for LC3 lipidation and autophagosome formation.
自噬体生物发生需要一种由 TMED9 和 SEC12 介导的新型 ERGIC-ERES 膜接触
影响因子：
44.1
作者：
Li S;Yan R;Xu J;Zhao S;Ma X;Sun Q;Zhang M;Li Y;Liu JG;Chen L;Li S;Xu K;Ge L
通讯作者：
Ge L