Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.
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DOI：
10.1016/j.phrs.2016.02.020
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发表时间：
2016-07
影响因子：
9.3
通讯作者：
Mottino AD
中科院分区：
文献类型：
--
作者：
Ghanem CI;Pérez MJ;Manautou JE;Mottino AD
对乙酰氨基酚(APAP)是一种著名的止痛和解热药物。在其治疗范围内给药被认为是安全的，但在急性中毒的情况下，可能会发生肝毒性。APAP过量是北半球急性肝功能衰竭的主要原因。从历史上看，对APAP毒性的研究一直集中在肝脏上，脑功能的改变可归因于急性肝功能衰竭的次要影响。然而，在过去的十年里，APAP作为一种大麻素系统调节剂的药理机制已经被记录在案，一些文章报道了APAP在高剂量下对脑组织的原位毒性。矛盾的是，据报道，低剂量的APAP会产生相反的神经保护作用。本文对APAP的肝脏毒性进行了全面、最新的综述，并对APAP对脑的毒性和有益作用进行了全面的综述。
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to be safe when administered within its therapeutic range, but in cases of acute intoxication, hepatotoxicity can occur. APAP overdose is the leading cause of acute liver failure in the northern hemisphere. Historically, studies on APAP toxicity have been focused on liver, with alterations in brain function attributed to secondary effects of acute liver failure. However, in the last decade the pharmacological mechanism of APAP as a cannabinoid system modulator has been documented and some articles have reported “in situ” toxicity by APAP in brain tissue at high doses. Paradoxically, low doses of APAP have been reported to produce the opposite, neuroprotective effects. In this paper we present a comprehensive, up-to-date overview of hepatic toxicity as well as a thorough review of both toxic and beneficial effects of APAP in brain.