Archaebacterial Tetraetherlipid Liposomes
Archaebacterial Tetraetherlipid Liposomes
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DOI：
10.1007/978-1-60327-360-2_5
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Bakowsky, Udo
中科院分区：
文献类型：
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作者：
Ozcetin, Aybike;Mutlu, Samet;Bakowsky, Udo
脂质体由于其作为药物递送系统的适用性而被广泛研究。然而，不稳定的脂质体构成是最大的限制之一，因为脂质体在应用于人体后经历快速消除。在本研究中，使用新型古生菌脂质制备脂质体制剂，测试其在高温、不同pH值和热灭菌后的稳定性。
Liposomes are widely investigated for their applicability as drug delivery systems. However, the unstable liposomal constitution is one of the greatest limitations, because the liposomes undergo fast elimination after application to the human body. In the presented study, novel archeal lipids were used to prepare liposomal formulations which were tested for their stability at elevated temperatures, at different pH-values and after heat sterilization.