Metabolism in tumor microenvironment: Implications for cancer immunotherapy.
Metabolism in tumor microenvironment: Implications for cancer immunotherapy.
复制标题
肿瘤微环境中的代谢：对癌症免疫治疗的影响
作者：
Shi R;Tang YQ;Miao H
摘要肿瘤微环境是肿瘤生存的特殊环境，具有缺氧、酸性、营养缺乏、免疫抑制等特点。环境由血管系统、免疫细胞、细胞外基质和蛋白质或代谢分子组成。最近的大量研究表明，不仅肿瘤细胞，而且肿瘤微环境中的免疫细胞都经历了代谢重编程，这与肿瘤耐药和恶性进展密切相关。基于T细胞的肿瘤免疫治疗给患者带来了新的希望，但面临着应答率低的困境。迫切需要新的策略来提高癌症免疫治疗的敏感性。代谢重编程可以直接影响肿瘤细胞的生物活性，也可以调节免疫细胞的分化和激活。作者就肿瘤微环境的特点、肿瘤相关免疫细胞的代谢变化以及代谢重编程在肿瘤免疫治疗中的调节作用作一综述。
Abstract Tumor microenvironment is a special environment for tumor survival, which is characterized by hypoxia, acidity, nutrient deficiency, and immunosuppression. The environment consists of the vasculature, immune cells, extracellular matrix, and proteins or metabolic molecules. A large number of recent studies have shown that not only tumor cells but also the immune cells in the tumor microenvironment have undergone metabolic reprogramming, which is closely related to tumor drug resistance and malignant progression. Tumor immunotherapy based on T cells gives patients new hope, but faces the dilemma of low response rate. New strategies sensitizing cancer immunotherapy are urgently needed. Metabolic reprogramming can directly affect the biological activity of tumor cells and also regulate the differentiation and activation of immune cells. The authors aim to review the characteristics of tumor microenvironment, the metabolic changes of tumor‐associated immune cells, and the regulatory role of metabolic reprogramming in cancer immunotherapy.
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影响因子：
20.3
作者：
Biswas, SK;Gangi, L;Sica, A
通讯作者：
Sica, A
DOI：
10.4274/mirt.galenos.2019.33866
发表时间：
2020-02-01
影响因子：
0.9
作者：
Arslan, Esra;Aksoy, Tamer;Cermik, Tevfik Fikret
通讯作者：
Cermik, Tevfik Fikret
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
影响因子：
32.4
作者：
Blagih, Julianna;Coulombe, Francois;Jones, Russell G.
通讯作者：
Jones, Russell G.
影响因子：
4.8
作者：
Almutairi, Saeedah Musaed;Ali, Alaa Kassim;Lee, Seung-Hwan
通讯作者：
Lee, Seung-Hwan