Pharmacological targeting of the tumor-immune symbiosis in glioblastoma.
Pharmacological targeting of the tumor-immune symbiosis in glioblastoma.
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DOI：
10.1016/j.tips.2022.04.002
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发表时间：
2022-08
影响因子：
13.8
通讯作者：
Chen, Peiwen
中科院分区：
文献类型：
--
作者：
Pang, Lizhi;Khan, Fatima;Dunterman, Madeline;Chen, Peiwen
胶质母细胞瘤（GBM）是成年人中最常见且高度致命的脑肿瘤形式。 - 免疫共生在这里成为GBM的有前途的理论策略。
Glioblastoma (GBM) is the most common and highly lethal form of primary brain tumor in adults. The median survival of GBM patients is approximately 14–16 months despite multimodal therapies. Emerging evidence has substantiated the critical role of symbiotic interactions between GBM cells and noncancerous immune cells (e.g., myeloid cells and T cells) in regulating tumor progression and therapy resistance. Approaches to target the tumor–immune symbiosis have emerged as a promising therapeutic strategy for GBM. Here, we review the recent developments for pharmacological targeting of the GBM-immune symbiosis and highlight the role of such strategies to improve the effectiveness of immunotherapies in GBM.
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DOI：
10.1158/1078-0432.ccr-18-0926
发表时间：
2019-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cruickshanks N;Zhang Y;Hine S;Gibert M;Yuan F;Oxford M;Grello C;Pahuski M;Dube C;Guessous F;Wang B;Deveau C;Saoud K;Gallagher I;Wulfkuhle J;Schiff D;Phan S;Petricoin E;Abounader R
通讯作者：
Abounader R
影响因子：
11.2
作者：
Chang AL;Miska J;Wainwright DA;Dey M;Rivetta CV;Yu D;Kanojia D;Pituch KC;Qiao J;Pytel P;Han Y;Wu M;Zhang L;Horbinski CM;Ahmed AU;Lesniak MS
通讯作者：
Lesniak MS
免疫基因组分析揭示 LGALS1 有助于神经胶质瘤的免疫异质性和免疫抑制
影响因子：
6.4
作者：
Chen, Qun;Han, Bo;Cai, Jinquan
通讯作者：
Cai, Jinquan
影响因子：
22.7
作者：
Arrieta VA;Chen AX;Kane JR;Kang SJ;Kassab C;Dmello C;Zhao J;Burdett KB;Upadhyayula PS;Lee-Chang C;Shilati J;Jaishankar D;Chen L;Gould A;Zhang D;Yuan J;Zhao W;Ling X;Burks JK;Laffleur B;Amidei C;Bruce JN;Lukas RV;Yamaguchi JT;Cieremans D;Rothschild G;Basu U;McCord M;Brat DJ;Zhang H;Cooper LAD;Zhang B;Sims P;Cloughesy TF;Prins R;Canoll P;Stupp R;Heimberger AB;Horbinski C;Iwamoto FM;Rabadan R;Sonabend AM
通讯作者：
Sonabend AM
影响因子：
17.1
作者：
Fidanza, Mario;Gupta, Puja;Wong, Albert J.
通讯作者：
Wong, Albert J.