Prevalence of hepatitis B virus infection and its associated factors among 15,461 pregnant women in Yunnan province, China
Prevalence of hepatitis B virus infection and its associated factors among 15,461 pregnant women in Yunnan province, China
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DOI：
10.1016/j.annepidem.2020.05.011
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发表时间：
2020-09-01
影响因子：
5.6
通讯作者：
Wen, Ying
中科院分区：
文献类型：
--
作者：
Liu, Jihong;Liu, Jue;Wen, Ying
目的：中国是世界上B型肝炎病毒（HBV）感染负担最重的国家。但目前国内关于孕妇中乙型肝炎表面抗原（B surface antigen，HBsAg）最新流行情况的研究报道较少。我们的目的是评估云南省孕妇HBV感染的患病率及其相关危险因素，云南省是一个血源性病毒相对较高的省份。方法：我们对2013年至2016年期间在云南进行常规产前筛查的15，641名孕妇进行了横断面研究。结果：在15,641例孕妇中，HBsAg阳性率为7.89%（95%可信区间（CI）为7.47%~ 8.31%）。多因素Logistic回归分析显示，高龄（>= 35岁;校正比值比[aOR]，2.43-2.59），哈尼族（aOR，1.97; 95% CI，1.22-3.17），失业妇女（aOR，1.88; 95% CI，1.30-2.72）、经产妇（aOR，1.21; 95% CI，1.05-1.40）和多胎妊娠（aOR，1.28; 95% CI，1.10-1.49）更可能感染HBV。HBV感染与剖宫产和早产相关，aOR分别为1.31（1.17-1.48）和1.23（1.00-1.51）。在亚组分析中，哈尼族和HBV感染之间的关联在35岁或以上的女性中显著更高（aOR = 5.15; 95% CI，1.51-17.55）结论：云南省15,641例孕妇HBV感染处于中度流行状态。高龄、哈尼族、失业、多胎妊娠和多产状态与HBV感染的患病率增加相关。在常规产前检查中应重视高危孕妇。(C)2020爱思唯尔公司All rights reserved.
Purpose: China has the world's largest burden of hepatitis B virus (HBV) infection. However, there are few studies reported on the latest prevalence of hepatitis B surface antigen (HBsAg) among pregnant women in China. We aimed to assess the prevalence of HBV infection and its associated risk factors among pregnant women in Yunnan, which is a province with relatively high prevalence of blood-borne viruses.Methods: We conducted a cross-sectional study of 15,641 pregnant women who underwent routine antenatal screening for HBsAg in Yunnan between 2013 and 2016. Logistic regression analyses were used to examine the associations between HBV infection and risk factors.Results: Overall, 7.89% (95% confidence interval (CI), 7.47%-8.31%) of the 15,641 pregnant women tested positive for HBsAg. Multivariable logistic regression analysis showed that advanced age (>= 35 years old; adjusted odds ratio [aOR], 2.43-2.59), Hani ethnicity (aOR, 1.97; 95% CI, 1.22-3.17), unemployed women (aOR, 1.88; 95% CI, 1.30-2.72), multigravidas (aOR, 1.21; 95% CI, 1.05-1.40), and multiparas (aOR, 1.28; 95% CI, 1.10-1.49) were more likely to be infected with HBV. HBV infection was associated with cesarean section and preterm birth, with aORs of 1.31 (1.17-1.48) and 1.23 (1.00-1.51), respectively. In the subgroup analysis, the association between Hani ethnicity and HBV infection was significantly higher in women aged 35 years or older (aOR = 5.15; 95% CI, 1.51-17.55) than in women younger than 35 years of age (aOR = 1.69; 95% CI, 1.00-2.86).Conclusions: HBV infection among 15,641 pregnant women was of high-intermediate endemicity in Yunnan, China. Advanced age, Hani ethnicity, unemployment, and multigravid and multiparous statuses were associated with an increased prevalence of HBV infection. High-risk pregnant women should be paid more attention during routine antenatal examination. (C) 2020 Elsevier Inc. All rights reserved.