Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.
Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.
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DOI：
10.18632/oncotarget.15650
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发表时间：
2017-05-09
期刊：
影响因子：
--
通讯作者：
Pasdar M
中科院分区：
文献类型：
--
作者：
Aktary Z;Alaee M;Pasdar M
斑珠蛋白（Plakoglobin），又称斑珠蛋白（Plakoglobin）。β-连环蛋白（β-catenin）是Armadillo蛋白家族的一员，是β -连环蛋白的一个副产物。斑珠蛋白是粘附连接和桥粒的组成部分，因此在细胞-细胞粘附的调节中起重要作用。与β -连环蛋白类似，斑珠蛋白除了在细胞-细胞粘附中发挥作用之外，还能够参与细胞信号传导。在这种情况下，β -连环蛋白作为Wnt信号通路的一个组成部分，具有良好的致癌潜力。相比之下，虽然一些研究表明斑珠蛋白在细胞/恶性肿瘤特异性背景下具有肿瘤促进活性，但它通常充当肿瘤/转移抑制剂。斑珠蛋白如何作为生长/转移抑制蛋白一直是，直到最近，不清楚。最近的证据表明，斑珠蛋白可能通过多种机制抑制肿瘤的发生和转移，包括抑制致癌信号，与肿瘤发生和转移中涉及的各种蛋白质的相互作用，以及调节参与这些过程的基因的表达。本文就斑珠蛋白抑制肿瘤发生和转移的机制作一综述。
Plakoglobin (also known as? -catenin) is a member of the Armadillo family of proteins and a paralog of β -catenin. Plakoglobin is a component of both the adherens junctions and desmosomes, and therefore plays a vital role in the regulation of cell-cell adhesion. Similar to β -catenin, plakoglobin is capable of participating in cell signaling in addition to its role in cell-cell adhesion. In this context, β -catenin has a well-documented oncogenic potential as a component of the Wnt signaling pathway. In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. This review is primarily focused on various mechanisms by which plakoglobin may inhibit tumorigenesis and metastasis.