Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.
Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.
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DOI：
10.3389/fnsys.2011.00011
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发表时间：
2011
影响因子：
3
通讯作者：
Cragg SJ
中科院分区：
文献类型：
--
作者：
Threlfell S;Cragg SJ
纹状体多巴胺能神经元和纹状体胆碱能中间神经元参与环境刺激的动机意义的信号传导并调节纹状体可塑性。多巴胺（DA）和乙酰胆碱（ACh）在纹状体内在多个水平上具有有效的相互作用，包括神经递质释放的突触前调节和靶细胞（包括ACh神经元）中的突触后效应。这些相互作用可能是高度可变的动态变化的父DA和ACh神经元的放电活动。在这里，我们考虑如何纹状体乙酰胆碱释放胆碱能中间神经元作用于烟碱和毒蕈碱乙酰胆碱受体强烈调制DA传输。这种ACh-DA相互作用的变化方式取决于突触前激活的频率，因此将强烈影响DA突触如何传达DA神经元活动的离散变化，这些变化已知会发出动机显着事件的信号。此外，这种乙酰胆碱调制纹状体内的DA传输发生通过不同的配置文件的烟碱和毒蕈碱受体在尾壳核相比，丘脑核，这可能最终使区域特异性靶向纹状体功能。
Mesostriatal dopaminergic neurons and striatal cholinergic interneurons participate in signaling the motivational significance of environmental stimuli and regulate striatal plasticity. Dopamine (DA) and acetylcholine (ACh) have potent interactions within the striatum at multiple levels that include presynaptic regulation of neurotransmitter release and postsynaptic effects in target cells (including ACh neurons). These interactions may be highly variable given the dynamic changes in the firing activities of parent DA and ACh neurons. Here, we consider how striatal ACh released from cholinergic interneurons acting at both nicotinic and muscarinic ACh receptors powerfully modulates DA transmission. This ACh–DA interaction varies in a manner that depends on the frequency of presynaptic activation, and will thus strongly influence how DA synapses convey discrete changes in DA neuron activity that are known to signal events of motivational salience. Furthermore, this ACh modulation of DA transmission within striatum occurs via different profiles of nicotinic and muscarinic receptors in caudate–putamen compared to nucleus accumbens, which may ultimately enable region-specific targeting of striatal function.