Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer's disease.
Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer's disease.
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DOI：
10.1042/ns20190068
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发表时间：
2019-12-01
影响因子：
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通讯作者：
Ferris, Heather A
中科院分区：
文献类型：
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作者：
Weigel, Thaddeus K;Kulas, Joshua A;Ferris, Heather A
2型糖尿病与中枢神经系统的不良影响有关，包括阿尔茨海默病（AD）的风险增加一倍，认知障碍的风险增加，但糖尿病与认知能力下降和痴呆症的联系机制尚不清楚。这些疾病之间的一个可能联系可能是脑中胆固醇氧化和代谢的相关改变。我们将调查证据表明改变在AD和糖尿病的大脑中的氧固醇，以及如何这些氧固醇可能有助于病理学，以及确定尚未得到解决的研究问题，以便更全面地了解氧固醇在AD和糖尿病中的作用。
Type 2 diabetes is associated with adverse central nervous system effects, including a doubled risk for Alzheimer's disease (AD) and increased risk of cognitive impairment, but the mechanisms connecting diabetes to cognitive decline and dementia are unknown. One possible link between these diseases may be the associated alterations to cholesterol oxidation and metabolism in the brain. We will survey evidence demonstrating alterations to oxysterols in the brain in AD and diabetes and how these oxysterols could contribute to pathology, as well as identifying research questions that have not yet been addressed to allow for a fuller understanding of the role of oxysterols in AD and diabetes.