Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging.
Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging.
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DOI：
10.1038/srep45696
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发表时间：
2017-04-04
影响因子：
4.6
通讯作者：
Wang M
中科院分区：
文献类型：
--
作者：
Ma X;Bai Y;Lin Y;Hong X;Liu T;Ma L;Haacke EM;Zhou J;Wang J;Wang M
酰胺质子转移（APT）成像是一种基于化学交换依赖的饱和转移机制的无创分子磁共振成像（MRI）技术。本研究的目的是通过与磁敏感加权成像（SWI）比较，探讨APT MRI在超急性、急性和亚急性阶段颅内出血（ICH）检测中的诊断性能。使用 3-T MRI 装置对 33 名 ICH 患者进行 APT MRI 和 SWI。采用双边 Mann-Whitney U 检验检测超急性、急性和亚急性阶段 ICH 的 APT 加权 (APTw) 和 SWI 信号强度差异。接受者操作特征分析用于评估 APT MRI 和 SWI 的诊断效用。我们的结果表明，APT MRI 可以检测超急性、急性和亚急性阶段的 ICH。因此，APTw信号强度可以作为检测超急性、急性和亚急性阶段ICH的可靠、无创成像生物标志物。此外，与 SWI 相比，APT MRI 可以为 ICH 提供更多信息。
Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (ICH) at hyperacute, acute and subacute stages by comparing with susceptibility weighted imaging (SWI). APT MRI and SWI were performed on 33 included patients with ICH by using a 3-T MRI unit. A two-sided Mann-Whitney U test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages. Receiver operating characteristic analysis was used to assess the diagnostic utilities of APT MRI and SWI. Our results showed that APT MRI could detect ICH at hyperacute, acute and subacute stages. Therefore, APTw signal intensity may serve as a reliable, noninvasive imaging biomarker for detecting ICH at hyperacute, acute and subacute stages. Moreover, APT MRI could provide additional information for the ICH compared with SWI.