Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa
Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa
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DOI：
10.1126/science.286.5444.1561
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发表时间：
1999-11-19
期刊：
影响因子：
56.9
通讯作者：
Miller, SI
中科院分区：
文献类型：
--
作者：
Ernst, RK;Yi, EC;Miller, SI
囊性纤维化（CF）患者发生慢性气道感染，铜绿假单胞菌（PA）在不同环境条件下合成具有多种五酰化和六酰化脂质a结构的脂多糖（LPS）。CF患者PA合成具有特定脂质A结构的LPS，表明对CF气道环境的独特识别。含有棕榈酸酯和阿拉伯氨基糖的cf特异性脂质A形式与对阳离子抗菌肽的耐药性和炎症反应增加有关，表明它们可能与气道疾病有关。
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA), Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific Lipid A structures indicating unique recognition of the CF airway environment. CF-specific Lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.