Development of polypoidal lesions in age-related macular degeneration
Development of polypoidal lesions in age-related macular degeneration
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年龄相关性黄斑变性息肉状病变的发展
DOI：
10.1038/eye.2010.232
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Yoshimura N.
中科院分区：
文献类型：
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作者：
Tsujikawa A;Ojima Y;Yamashiro K;Ooto S;Tamura H;Nakata I;Yoshimura N.
目的应用吲哚菁绿血管造影（IA）观察典型老年性黄斑变性（AMD）患者息肉样病变的发生。方法回顾性分析47例典型黄斑变性患者（47只眼）连续2年以上的眼科随访资料。结果首次就诊时，虽然所有的眼睛都表现出与AMD相关的典型和/或隐匿脉络膜新生血管（CNV），但没有眼睛显示息肉样病变。然而，在随访期间，47只眼中有13只（27.7%）出现息肉样病变。所有息肉样病变都发生在持续性CNV的边缘，更常见的是发生在最近进展的CNV的末端。12只眼最终病变面积为48cm，其中7只（58.3%）出现新发息肉样病变。新发息肉样病变眼，随访时血管病变的平均面积由10.50±7.88 mm 2显著扩大至20.87±10.21 mm 2 （P= 0.0018）。结论活动性黄斑变性视网膜色素上皮间隙内CNV进展时，IA可显示息肉样病变。
PurposeTo investigate the development of polypoidal lesions using indocyanine green angiography (IA) in eyes with typical age-related macular degeneration (AMD).MethodsWe retrospectively reviewed the medical records of 47 consecutive patients (47 eyes) with typical AMD who had been followed up with IA for at least 2 years.ResultsAt the initial visit, although all eyes showed classic and/or occult choroidal neovascularization (CNV) associated with AMD, no eyes showed polypoidal lesions by IA. However, during follow-up, 13 (27.7%) of the 47 eyes did show polypoidal lesions. All polypoidal lesions developed at the edge of persistent CNV or, more often, at the terminus of recently progressed CNV. Of 12 eyes with a final lesion area> 8 disc area, 7 (58.3%) showed newly developed polypoidal lesions. In the eyes with these newly developed polypoidal lesions, the mean area of the vascular lesion had extended significantly from 10.50±7.88 mm 2 to 20.87±10.21 mm 2 during follow-up (P= 0.0018).ConclusionThe current observation suggests that IA of active AMD sometimes reveals polypoidal lesions if there is progression of the CNV in the subretinal pigment epithelium space.