The seroprevalences of anti-hantavirus IgG antibodies among selected Venezuelan populations
The seroprevalences of anti-hantavirus IgG antibodies among selected Venezuelan populations
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DOI：
10.1179/000349803125002788
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发表时间：
2003-01-01
影响因子：
--
通讯作者：
Ludert, JE
中科院分区：
文献类型：
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作者：
Rivas, YJ;Moros, Z;Ludert, JE
在委内瑞拉，从啮齿动物身上分离出汉坦病毒，并在1999年检测到一例临床确诊的人感染汉坦病毒病例，导致人们对这些病毒的兴趣增加。为了评估此类病毒在委内瑞拉造成的问题，采用基于纯化、重组核蛋白的ELISA法检测了1380份人血清样本中是否存在汉坦病毒抗体。经间接免疫荧光和免疫印迹试验证实，23份(1.7%)血清标本中含有汉坦病毒抗体。在所有年龄组和性别中，血清流行率都是相似的，在接触啮齿动物风险相对较高的农村人口中并不高于整个研究人群。虽然样本数量很少，但卡拉博州居民的血清阳性率远远高于总体水平(10.3%，vs.1.7%；P<；0.01)。人类感染汉坦病毒似乎并不常见，但在委内瑞拉广泛分布。
In Venezuela, the isolation of hantaviruses from rodents and the detection, in 1999, of a clinically confirmed human case of hantavirus infection led to increased interest in these viruses. In an attempt to estimate the problem posed by such viruses in Venezuela, ELISA based on purified, recombinant, nucleoprotein were used to check 1380 human serum samples for the presence of IgG antibodies to hantavirus. The ELISA results, as confirmed by indirect immunofluorescence and Western-blot assays, indicated that 23 (1.7%) of the serum samples contained antibodies to hantaviruses. Seroprevalences were similar among all age-groups and for both genders and were no higher among rural populations with a relatively high risk of exposure to rodents than among the overall study population. Although the numbers of samples involved were small, the seroprevalence among the subjects who were residents of Carabobo state was much higher than the overall value (10.3%, v. 1.7%; P < 0.01). Human infection with hantavirus appears uncommon but widely distributed in Venezuela.