Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation.
Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation.
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DOI：
10.3389/fimmu.2015.00585
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发表时间：
2015
影响因子：
7.3
通讯作者：
Chen BK
中科院分区：
文献类型：
--
作者：
Swartz TH;Dubyak GR;Chen BK
1 型人类免疫缺陷病毒 (HIV-1) 会导致慢性感染，全世界有超过 3000 万人受到影响。虽然可以通过有效的抗逆转录病毒疗法抑制感染，但感染 HIV-1 的个体炎症水平升高，如 T 细胞活化、可溶性生物标志物增加以及相关的发病率和死亡率所示。将 HIV-1 发病机制与这种炎症联系起来的单一机制尚未确定。已知嘌呤能受体可介导炎症，并且已被证明是 HIV-1 膜融合水平的 HIV-1 感染所必需的。在这里，我们回顾了有关嘌呤能受体在 HIV-1 感染和相关炎症中的作用的文献，并描述了这些受体作为潜在治疗靶点的作用。
Human immunodeficiency virus type 1 (HIV-1) causes a chronic infection that afflicts more than 30 million individuals worldwide. While the infection can be suppressed with potent antiretroviral therapies, individuals infected with HIV-1 have elevated levels of inflammation as indicated by increased T cell activation, soluble biomarkers, and associated morbidity and mortality. A single mechanism linking HIV-1 pathogenesis to this inflammation has yet to be identified. Purinergic receptors are known to mediate inflammation and have been shown to be required for HIV-1 infection at the level of HIV-1 membrane fusion. Here, we review the literature on the role of purinergic receptors in HIV-1 infection and associated inflammation and describe a role for these receptors as potential therapeutic targets.