Antibody indications of secondary and superimposed retinal hypersensitivity in retinitis pigmentosa.
Antibody indications of secondary and superimposed retinal hypersensitivity in retinitis pigmentosa.
复制标题
色素性视网膜炎继发性和叠加性视网膜过敏的抗体适应症。
DOI：
10.1016/s0002-9394(14)76691-7
复制
发表时间：
1991
影响因子：
4.2
通讯作者：
Keltner,JL
中科院分区：
文献类型：
--
作者：
Thirkill,CE;Roth,AM;Takemoto,DJ;Tyler,NK;Keltner,JL
抗体反应与公认的视网膜病变诱导视网膜抗原可以解释为反映正在进行的自身免疫事件负责某些形式的视力丧失。我们在随机的色素性视网膜炎患者中寻找由这种抗体反应性指示的继发性和叠加性视网膜超敏反应的证据。我们确定了52例视网膜色素变性患者的免疫反应模式，这表明一些视网膜色素变性患者可能会出现相应的视网膜超敏反应。识别对已知葡萄膜致病性视网膜蛋白表现出视网膜过敏迹象的视网膜色素性视网膜炎患者亚组可能允许通过免疫调节降低其视网膜降解率。
Antibody reactions with recognized retinopathy-inducing retinal antigens may be interpreted to reflect ongoing autoimmune events responsible for some forms of vision loss. We sought evidence of secondary and superimposed retinal hypersensitivity indicated by such antibody reactivity in a random group of patients with retinitis pigmentosa. We identified patterns of immunologic reactivity within members of a group of 52 patients with retinitis pigmentosa, which suggests some patients with retinitis pigmentosa may experience consequential superimposed retinal hypersensitivity. Identifying subgroups of patients with retinitis pigmentosa who exhibit indications of retinal hypersensitivity to known uveitopathogenic retinal proteins may permit the reduction of their rate of retinal degradation by immunomodulation.