Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs.
Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs.
复制标题
用于成像过表达癌基因 mRNA 的肿瘤靶向肽-PNA-肽嵌合体。
DOI：
10.1081/ncn-200059177
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Wickstrom,E
中科院分区：
文献类型：
--
作者：
Tian,X;Aruva,MR;Wolfe,HR;Qin,W;Sauter,ER;Thakur,ML;Waldman,SA;Wickstrom,E
We have optimized a method involving continuous solid phase synthesis of chelator-peptide-PNA-peptide probes in order to noninvasively image oncogene mRNAs overexpressed in tumors. The PNA (peptide nucleic acid) probes carry cyclized peptide ligand analogs specific for receptors overexpressed on malignant breast or colorectal cancer cells, and chelators to bind radioactive metal ions, or a fluorophore. In vivo scintigraphic imaging of MCF7 xenografts in immunocompromised mice indicated that CCND1 and MYC [99mTc]chelator-PNA-D(CSKC) probes concentrated in MCF7 cells up to 7 times more than the corresponding mismatch controls.
