Hippocampal Global Remapping Can Occur without Input from the Medial Entorhinal Cortex
Hippocampal Global Remapping Can Occur without Input from the Medial Entorhinal Cortex
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DOI：
10.1016/j.celrep.2018.02.082
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发表时间：
2018-03
期刊：
影响因子：
8.8
通讯作者：
M. I. Schlesiger;Brittney L. Boublil;J. Hales;J. Leutgeb;S. Leutgeb
中科院分区：
文献类型：
--
作者：
M. I. Schlesiger;Brittney L. Boublil;J. Hales;J. Leutgeb;S. Leutgeb
情景记忆系统的高存储容量依赖于时间和空间上分离的事件的不同表示。这些计算的空间部分包括海马位置细胞跨环境形成独立地图，称为全局重映射。这种重新映射被认为是通过内侧内嗅皮层（mEC）中专门的空间选择性细胞（例如网格细胞和边缘细胞）的输入模式的切换而出现的。尽管已经表明，对 mEC 放电模式的急性操作足以诱导海马重新映射，但仍不清楚专门的空间 mEC 输入对于海马空间表征的重组是否必要。在这里，我们检查了没有 mEC 输入海马的大鼠的重新映射，发现每只大鼠中都迅速出现了高度不同的空间图。我们的数据表明海马空间计算不依赖于 mEC 中特殊细胞类型的输入。
The high storage capacity of the episodic memory system relies on distinct representations for events that are separated in time and space. The spatial component of these computations includes the formation of independent maps by hippocampal place cells across environments, referred to as global remapping. Such remapping is thought to emerge by the switching of input patterns from specialized spatially selective cells in medial entorhinal cortex (mEC), such as grid and border cells. Although it has been shown that acute manipulations of mEC firing patterns are sufficient for inducing hippocampal remapping, it remains unknown whether specialized spatial mEC inputs are necessary for the reorganization of hippocampal spatial representations. Here, we examined remapping in rats without mEC input to the hippocampus and found that highly distinct spatial maps emerged rapidly in every individual rat. Our data suggest that hippocampal spatial computations do not depend on inputs from specialized cell types in mEC.