TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus
TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus
复制标题
TXU（抗 CD7）-美洲商陆抗病毒蛋白作为人类免疫缺陷病毒的有效抑制剂
DOI：
10.1128/aac.42.2.383
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发表时间：
1998
影响因子：
4.9
通讯作者：
D. E. Myers
中科院分区：
文献类型：
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作者：
F. Uckun;L. Chelstrom;L. Tuel;I. Dibirdik;J. Irvin;Mridula;D. E. Myers
ABSTRACT We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-severe combined immunodeficient (Hu-PBL-SCID) mouse model of human AIDS. The present report documents in a side-by-side comparison the superior in vitro anti-HIV-1 activity of TXU-PAP compared to the activities of zidovudine, 2′,3′-didehydro-2′,3′-dideoxythymidine, unconjugated PAP, and B53-PAP, an anti-CD4-PAP immunoconjugate. Notably, TXU-PAP elicited potent anti-HIV activity in the Hu-PBL-SCID mouse model of human AIDS without any side effects and at doses that were very well tolerated by cynomolgus monkeys. Furthermore, plasma samples from TXU-PAP-treated cynomolgus monkeys showed potent anti-HIV-1 activity in vitro.
TXU（抗 CD7）-商陆抗病毒蛋白免疫毒素的体内毒性、药代动力学和抗白血病活性。
DOI：
--
发表时间：
1997
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research.
影响因子：
--
作者：
Waurzyniak,B;Schneider,EA;Tumer,N;Yanishevski,Y;Gunther,R;Chelstrom,LM;Wendorf,H;Myers,DE;Irvin,JD;Messinger,Y;Ek,O;Zeren,T;Langlie,MC;Evans,WE;Uckun,FM
通讯作者：
Uckun,FM
大规模生产用于临床试验的 TXU（抗 CD7）-美洲商陆抗病毒蛋白（PAP）免疫偶联物。
影响因子：
2.6
作者：
Myers,DE;Jun,X;Clementson,D;Donelson,R;Sicheneder,A;Hoffman,N;Bell,K;Sarquis,M;Langlie,MC;Turner,N;Uckun,FM
通讯作者：
Uckun,FM