Nociceptive sensory neurons derive from contralaterally migrating, fate-restricted neural crest cells
Nociceptive sensory neurons derive from contralaterally migrating, fate-restricted neural crest cells
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DOI：
10.1038/nn1962
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发表时间：
2007-10-01
影响因子：
25
通讯作者：
Lefcort, Frances
中科院分区：
文献类型：
--
作者：
George, Lynn;Chaverra, Marta;Lefcort, Frances
神经嵴细胞（NCC）是多能祖细胞的瞬时群体，其在胚胎中产生多种细胞类型。一个尚未解决的问题是NCC的命运在多大程度上是指定之前，他们从神经管移民。在鸡胚中，我们确定了一个NCC亚群，分层后，越过背中线殖民对侧背根神经节（DRG），在那里他们后来引起了近一半的伤害感受器感觉神经元人口的空间离散区域。我们的数据表明，在移民之前，这个NCC子集是表型不同的，具有内在的谱系潜力，不同于其时间同步，但同侧迁移，队列。这些发现不仅确定了疼痛和温度感应传入祖细胞的主要来源，而且还揭示了一种以前未知的感觉命运NCC的迁移途径，该途径需要跨越胚胎中线的能力。
Neural crest cells (NCCs) are a transient population of multipotent progenitors that give rise to numerous cell types in the embryo. An unresolved issue is the degree to which the fate of NCCs is specified prior to their emigration from the neural tube. In chick embryos, we identified a subpopulation of NCCs that, upon delamination, crossed the dorsal midline to colonize spatially discrete regions of the contralateral dorsal root ganglia (DRG), where they later gave rise to nearly half of the nociceptor sensory neuron population. Our data indicate that before emigration, this NCC subset is phenotypically distinct, with an intrinsic lineage potential that differs from its temporally synchronized, but ipsilaterally migrating, cohort. These findings not only identify a major source of progenitor cells for the pain- and temperature-sensing afferents, but also reveal a previously unknown migratory pathway for sensory-fated NCCs that requires the capacity to cross the embryonic midline.