Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.
Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.
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DOI：
10.1021/acsinfecdis.1c00091
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发表时间：
2021-07-09
影响因子：
5.3
通讯作者：
Buckner, Frederick S.
中科院分区：
文献类型：
--
作者：
Gelb, Michael H.;Buckner, Frederick S.
In this Viewpoint we provide a brief description of two efforts to develop drugs to treat diseases caused by tropical parasites (Malaria, human African trypanosomiasis, and Chagas disease). These efforts are largely based in a University setting but draw heavily on Pharma for a complete progression from drug hit discovery to advancement toward clinical trials. The first case is the development of protein farnesyltransferase inhibitors, and the second case is a series of benzthiazoles, the target of which is being investigated.
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影响因子：
4.2
作者：
Buchynskyy, Andriy;Gillespie, J. Robert;Gelb, Michael H.
通讯作者：
Gelb, Michael H.
影响因子：
120.1
作者：
Swinney, David C.;Anthony, Jason
通讯作者：
Anthony, Jason
影响因子：
4.2
作者：
Nagendar, Pendem;Gillespie, J. Robert;Buckner, Frederick S.
通讯作者：
Buckner, Frederick S.
影响因子：
7.3
作者：
Glenn, Matthew P.;Chang, Sung-Youn;Hamilton, Andrew D.
通讯作者：
Hamilton, Andrew D.
影响因子：
7.3
作者：
Tatipaka HB;Gillespie JR;Chatterjee AK;Norcross NR;Hulverson MA;Ranade RM;Nagendar P;Creason SA;McQueen J;Duster NA;Nagle A;Supek F;Molteni V;Wenzler T;Brun R;Glynne R;Buckner FS;Gelb MH
通讯作者：
Gelb MH