Alternative splicing and tumor progression.
Alternative splicing and tumor progression.
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DOI：
10.2174/138920208786847971
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发表时间：
2008-12
期刊：
影响因子：
2.6
通讯作者：
Biamonti G
中科院分区：
文献类型：
--
作者：
Ghigna C;Valacca C;Biamonti G
选择性剪接是增加真核生物蛋白质组功能多样性的重要分子机制。大量的实验数据表明，包括癌症在内的各种人类疾病中存在异常剪接。顺式作用剪接元件的突变和剪接调节因子的表达和/或活性的改变都极大地影响许多癌症相关基因的剪接谱。此外，在特定类型的癌症中，几种癌症相关基因的剪接谱发生了改变，这证明了特定剪接异构体在肿瘤进展中的直接作用。破译癌症中异常剪接的潜在机制可能对理解剪接机制如何被控制并与其他细胞过程整合至关重要，特别是转录和信号传导途径。此外，癌症中剪接失调的表征将导致对恶性转化的更好理解。癌症相关的选择性剪接变异体可能是癌症诊断和分类的新工具，也可能是基于高选择性剪接校正方法的创新治疗干预的靶点。
Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in various human diseases, including cancer. Both mutations in cis-acting splicing elements and alterations in the expression and/or activity of splicing regulatory factors drastically affect the splicing profile of many cancer-associated genes. In addition, the splicing profile of several cancer-associated genes is altered in particular types of cancer arguing for a direct role of specific splicing isoforms in tumor progression. Deciphering the mechanisms underlying aberrant splicing in cancer may prove crucial to understand how splicing machinery is controlled and integrated with other cellular processes, in particular transcription and signaling pathways. Moreover, the characterization of splicing deregulation in cancer will lead to a better comprehension of malignant transformation. Cancer-associated alternative splicing variants may be new tools for the diagnosis and classification of cancers and could be the targets for innovative therapeutical interventions based on highly selective splicing correction approaches.
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影响因子：
14.9
作者：
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通讯作者：
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