Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women.
Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women.
复制标题
绝经后妇女的糖尿病、代谢综合征和冠状动脉疾病的血管造影进展。
DOI：
10.1161/01.atv.0000191656.71812.7c
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Herrington,DavidM
中科院分区：
文献类型：
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作者：
Mellen,PhilipB;Cefalu,WilliamT;Herrington,DavidM
尽管代谢综合征（MS）与心血管风险增加有关，但其与动脉粥样硬化进展的关系尚不明确。我们试图确定是否MS预测冠状动脉粥样硬化性心脏病的进展血管造影在一个队列的绝经后women.Methods和结果，共309名绝经后妇女进入雌激素替代和动脉粥样硬化试验，其中248人进行了基线血管造影，并完成了随访血管造影后，平均3.2年。女性被确定为患有2型糖尿病（T2 DM）或MS（国家胆固醇教育小组诊断标准）。在调整后的模型中，患有T2 DM和MS的受试者的血管造影进展[最小直径变化（ΔMD）：-0.15]大于未患有T2 DM或MS的女性（ΔMD：-0.08;P<0.05）或仅患有MS的女性（ΔMD：-0.07;P<0.005）;未患有T2 DM的女性中MS状态的进展没有差异（P=0.54）]。在校正的logistic回归模型中，T2 DM可预测冠心病事件[比值比，2.79（95%CI，1.29至6.02）]，MS显示出类似的趋势[比值比，1.98（95%CI，0.90 ~ 4.33）].结论-在绝经后冠心病妇女中，糖尿病的存在预示着疾病的进展，但MS不能。
Objective—Although the metabolic syndrome (MS) is associated with increased cardiovascular risk, its relationship with atherosclerotic progression is less well defined. We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women.Methods and Results—A total of 309 postmenopausal women entered the Estrogen Replacement and Atherosclerosis trial, of whom 248 underwent baseline angiography and completed follow-up angiography after an average of 3.2 years. Women were identified as having type 2 diabetes mellitus (T2DM) or the MS (National Cholesterol Education Panel diagnostic criteria). In adjusted models, participants with T2DM and the MS had greater angiographic progression [change in minimal diameter (ΔMD): −0.15] than women without T2DM or the MS (ΔMD: −0.08;P<0.05) or with MS alone (ΔMD: −0.07;P<0.005); there was no difference in progression by MS status in women without T2DM (P=0.54)]. In adjusted logistic regression models, T2DM predicted coronary heart disease events [odds ratio, 2.79 (95% CI, 1.29 to 6.02)], and the MS demonstrated a similar trend [odds ratio, 1.98 (95% CI, 0.90 to 4.33)].Conclusions—Among postmenopausal women with coronary heart disease, the presence of diabetes predicted disease progression, but the MS did not.