Understanding perirhinal contributions to perception and memory: Evidence through the lens of selective perirhinal damage
Understanding perirhinal contributions to perception and memory: Evidence through the lens of selective perirhinal damage
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DOI：
10.1016/j.neuropsychologia.2018.12.020
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发表时间：
2019-02-01
期刊：
影响因子：
2.6
通讯作者：
Davachi, Lila
中科院分区：
文献类型：
--
作者：
Inhoff, Marika C.;Heusser, Andrew C.;Davachi, Lila
虽然内侧颞叶（MU）的记忆系统观点在理解记忆过程是如何实现的方面具有广泛的影响力，但人类和动物的大量工作都集中在MTL可以支持各种其他决策的想法上，而不仅仅是那些涉及记忆的决策。具体来说，最近的工作表明，对视觉表征的感知和记忆可能会相互作用，以支持持续的认知。然而，考虑到神经心理学研究中的病变概况和功能磁共振成像的相关性，MTL支持的表征的确切性质在人类中还没有得到很好的理解。在本研究中，三名MTL高度特异性病变的患者进行了一项任务，征税的知觉和记忆判断高度相似的面部刺激。观察到显著的双重解离，使得I.R.，患有局限于右后PRc的囊肿的患者在知觉辨别方面表现出显著的损害，而患者A.N.，在右后海马旁皮质和右海马尾部有损伤的个体，和S.D.，双侧海马损伤的个体在知觉任务上没有表现出受损的表现。A.N.和S.D.然而，确实显示出记忆能力的损伤，而患者I.R.没有。这些结果因果牵连正确的PRc在成功的感知奇怪的判断，但他们建议，表示支持PRc是不必要的正确的记忆判断，即使在高功能重叠的情况下。
Although a memory systems view of the medial temporal lobe (MU) has been widely influential in understanding how memory processes are implemented, a large body of work across humans and animals has converged on the idea that the MTL can support various other decisions, beyond those involving memory. Specifically, recent work suggests that perception of and memory for visual representations may interact in order to support ongoing cognition. However, given considerations involving lesion profiles in neuropsychological investigations and the correlational nature of fMRI, the precise nature of representations supported by the MTL are not well understood in humans. In the present investigation, three patients with highly specific lesions to MTL were administered a task that taxed perceptual and mnemonic judgments with highly similar face stimuli. A striking double dissociation was observed such that I.R., a patient with a cyst localized to right posterior PRc, displayed a significant impairment in perceptual discriminations, whereas patient A.N., an individual with a lesion in right posterior parahippocampal cortex and the tail of the right hippocampus, and S.D., an individual with bilateral hippocampal damage, did not display impaired performance on the perceptual task. A.N. and S.D. did, however, show impairments in memory performance, whereas patient I.R. did not. These results causally implicate right PRc in successful perceptual oddity judgments, however they suggest that representations supported by PRc are not necessary for correct mnemonic judgments, even in situations of high featural overlap.