The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment
The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment
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转录因子 OsSUF4 与 SDG725 相互作用促进 H3K36me3 建立
DOI：
10.1038/s41467-019-10850-5
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发表时间：
2019-07-05
影响因子：
16.6
通讯作者：
Dong, Aiwu
中科院分区：
文献类型：
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作者：
Liu, Bing;Liu, Yuhao;Dong, Aiwu
不同物种中 H3K36 (H3K36me3) 三甲基化的不同基因组分布表明进化过程中 H3K36me3 建立的机制不同。在这里，我们发现转录因子 OsSUF4 识别特定的 7 bp DNA 元件，广泛分布在整个水稻基因组中，并招募 H3K36 甲基转移酶 SDG725 来靶向一组基因，包括促进水稻开花的关键成花基因 RFT1 和 Hd3ato。生化和结构分析表明，锌指结构域内的几个阳性残基对于植物中的 OsSUF4 功能至关重要。我们的结果揭示了有助于 H3K36me3 在植物中分布的调节机制。
The different genome-wide distributions of tri-methylation at H3K36 (H3K36me3) in various species suggest diverse mechanisms for H3K36me3 establishment during evolution. Here, we show that the transcription factor OsSUF4 recognizes a specific 7-bp DNA element, broadly distributes throughout the rice genome, and recruits the H3K36 methyltransferase SDG725 to target a set of genes including the key florigen genesRFT1andHd3ato promote flowering in rice. Biochemical and structural analyses indicate that several positive residues within the zinc finger domain are vital for OsSUF4 function in planta. Our results reveal a regulatory mechanism contributing to H3K36me3 distribution in plants.