WNT and beta-catenin signalling: diseases and therapies.
WNT and beta-catenin signalling: diseases and therapies.
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发表时间：
2004
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影响因子：
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通讯作者：
R. Moon;A. D. Kohn;G. D. De Ferrari;A. Kaykas
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作者：
R. Moon;A. D. Kohn;G. D. De Ferrari;A. Kaykas
WNT信号主要在发育中的胚胎中进行研究，其中细胞通过生存和增殖，细胞命运和运动的变化以上下文依赖的方式对WNT做出反应。但WNT在成人中也具有重要功能，WNT途径的异常信号传导与一系列疾病有关，最明显的是癌症。涉及WNT途径的疾病有哪些？抑制WNT信号传导能否成为某些癌症有效治疗的基础？WNT信号的激活能否为其他临床疾病提供新的治疗方法？最后，在最近的实验的基础上，WNTs是否通常参与干细胞的自我更新、增殖或分化？如果是这样的话，改变WNT信号可能有利于干细胞用于治疗手段。
WNT signalling has been studied primarily in developing embryos, in which cells respond to WNTs in a context-dependent manner through changes in survival and proliferation, cell fate and movement. But WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer. What is the full range of diseases that involve WNT pathways? Can inhibition of WNT signalling form the basis of an effective therapy for some cancers? Could activation of WNT signalling provide new therapies for other clinical conditions? Finally, on the basis of recent experiments, might WNTs normally participate in self-renewal, proliferation or differentiation of stem cells? If so, altering WNT signalling might be beneficial to the use of stem cells for therapeutic means.