Factors influencing the size distribution of aerosols from jet nebulisers.
Factors influencing the size distribution of aerosols from jet nebulisers.
复制标题
影响喷射雾化器气溶胶粒径分布的因素。
作者：
M. Clay;D. Pavia;S. Newman;S. Clarke
使用马尔文2200激光粒度分析仪测量了四种广泛使用的喷射雾化器（Acorn、Upmist、Turret和ECONT Mini-neb）产生的盐水和支气管扩张剂（特布他林）气溶胶液滴的粒度分布。压缩空气的驱动流量对每个雾化器产生的气溶胶液滴的质量中值直径有很大影响。通过将流速从4增加到8 1 min-1，质量中值直径减半（p <0.01），并且在最佳可吸入范围内（小于5 μ m）的气雾剂质量增加。为了达到该范围，需要以下单独的流速：转塔4 1 min-1，Acorn和Upmist 6 1 min-1，以及Doppler Mini-neb 8 1 min-1。发现质量中值直径和几何标准差之间存在显著的负相关（p <0.001），表明气溶胶在高流速下更小但更不均匀分散。药物浓度的变化对气溶胶粒径的影响不大。在72%的雾化干燥后，在雾化过程中质量中值直径没有显著变化，其余的小于1.3微米。
The size distribution of saline and bronchodilator (terbutaline) aerosol droplets generated from four widely used jet nebulisers (Acorn, Upmist, Turret, and Inspiron Mini-neb) has been measured with a Malvern 2200 Laser Particle Sizer. The mass median diameter of aerosol droplets generated by each nebuliser was strongly influenced by the driving flow rate of compressed air. By increasing the flow rate from 4 to 8 1 min-1 mass median diameters were halved (p less than 0.01) and there was an increase in the mass of aerosol within the optimum respirable range (less than 5 micron). To achieve this range the following individual flow rates were required: Turret 4 1 min-1, Acorn and Upmist 6 1 min-1, and Inspiron Mini-neb 8 1 min-1. A significant inverse relation (p less than 0.001) was found between mass median diameter and the geometric standard deviation, indicating that the aerosols were smaller but more heterodisperse at high flow rates. Changes in drug concentration had little effect on aerosol size. In 72% of the nebulisations followed to dryness there was no significant change in mass median diameter during the course of nebulisation and in the remainder it was less than 1.3 micron.