LYSYL OXIDASE AND RRG MESSENGER-RNA
LYSYL OXIDASE AND RRG MESSENGER-RNA
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DOI：
10.1126/science.1678898
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发表时间：
1991-08-16
期刊：
影响因子：
56.9
通讯作者：
FRIEDMAN, RM
中科院分区：
文献类型：
--
作者：
KENYON, K;CONTENTE, S;FRIEDMAN, RM
最近几个ofus报道rrg基因是ras的一个假定的肿瘤抑制基因或抑癌基因（1）。小鼠NIH 3T3细胞系经ras基因转化后几乎不表达rrg，而非转化的NIH 3T3细胞系和干扰素回复的细胞系则相反。回复突变体继续表达ras p21和mRNA的数量与转化细胞系的表达量相当。用反义表达构建体转染的回复突变体细胞系被再转化。这些数据
Several ofus recently reported that the rrg gene was a putative tumor suppressor gene or anti-oncogene of ras (1). Mouse NIH 3T3 cell lines transformed by ras expressed almost no rrg, in contrast with nontrans-formed NIH 3T3 cell lines and interferonreverted cell lines. Revertants continued to express ras p21 and mRNA in amounts comparable to those expressed by trans-formed cell lines. A revertant cell line trans-fected with an rrgantisense expression construct became retransformed. These data