Amine oxidases and tumors
Amine oxidases and tumors
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DOI：
10.1016/s0161-813x(03)00109-8
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发表时间：
2004-01-01
期刊：
影响因子：
3.4
通讯作者：
Mondovì, B
中科院分区：
文献类型：
--
作者：
Pietrangeli, P;Mondovì, B
胺氧化酶在生物体中的生理功能尚未完全确定，但肯定与生物胺代谢有关，因此参与细胞生长和分化等重要过程。已有报道称肿瘤恶性程度与AO活性水平之间存在相关性。胺（过氧化氢和氨基醛）氧化脱氨基的催化产物具有细胞毒性作用，被认为是细胞生长抑制剂。生物胺在细胞中同样可以被认为既是毒物又是保护者。氧化剂和抗氧化剂酶的平衡似乎在致癌和细胞生长调节中非常重要。(C)2003年爱思唯尔公司All rights reserved.
The physiological function in living organisms of amine oxidases, is not completely established but is certainly related to the biogenic amines metabolism and therefore involved in essential processes such as the cell growth and differentiation. A correlation between degree of tumor malignancy and level of AO activity has been reported. The catalytic products of oxidative deamination of amines (hydrogen peroxide and aminoaldehyde) exert a cytotoxic effect and are considered cell growth inhibitors. The biogenic amines in same way could be considered in the cells as both poisons and protectors. A balance of oxidant and antioxidant enzymes appears to be very important in carcinogenesis and cell growth regulation. (C) 2003 Elsevier Inc. All rights reserved.