Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder
Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder
复制标题
DOI：
10.1016/s0304-3940(02)01029-7
复制
发表时间：
2002-12-06
影响因子：
2.5
通讯作者：
Leboyer, M
中科院分区：
文献类型：
--
作者：
Bellivier, F;Leroux, M;Leboyer, M
5-羟色胺转运体（SLC 6A 4）基因多态性与几种行为和精神性状相关。在双相情感障碍中，SLC 6A 4基因的两种多态性，第二内含子中可变数目的串联重复序列和5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）中的44个插入/缺失，已被广泛研究。研究结果是相互矛盾的，可能是因为双相情感障碍的异质性。早发性双相情感障碍在临床和遗传学上似乎更为同质，最近被认为与5-HTTLPR多态性有关。我们在双相患者样本中检测了SLC 6A 4基因的两种多态性与发病年龄（AAO）之间的相关性。比较两种SLC 6A 4基因多态性在不同基因型受试者中的AAO。比较不同AAO组SLC 6A 4基因型分布。可变数量串联重复序列（VNTR）多态性显着影响AAO，但5-羟色胺转运蛋白基因连锁多态性区域（5-HTTLPR）多态性没有影响。携带至少一个VNTR STin2.12等位基因的患者发病较晚，而携带“ss”基因型的患者往往开始发病较早。差异抽样程序可能会影响AAO亚组在一个给定的关联研究中的比例，因此这些结果可能会解释在SLC 6A 4基因多态性和双相情感障碍（BPAD）之间的关联研究中获得的相互矛盾的结果。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Serotonin transporter (SLC6A4) gene polymorphism is associated with several behavioral and psychiatric traits. In bipolar affective disorder, two polymorphisms of the SLC6A4 gene, a variable number of tandem repeats in the second intron and a 44 by insertion/deletion in the serotonin transporter gene linked polymorphic region (5-HTTLPR), have been extensively studied. The findings are conflicting possibly because of the heterogeneity of bipolar disorder. Early-onset bipolar disorder appears to be clinically and genetically more homogeneous and was recently suggested to be associated with the 5-HTTLPR polymorphism. We tested the association between two polymorphisms of the SLC6A4 gene and age at onset (AAO) in a sample of bipolar patients. For both SLC6A4 gene polymorphisms, AAO of subjects with different genotypes were compared. SLC6A4 genotype distributions of different AAO groups were also compared. The variable number of tandem repeats (VNTR) polymorphism significantly influences the AAO but the serotonin transporter gene linked polymorphic region (5-HTTLPR) polymorphism did not. Patients carrying at least one VNTR STin2.12 allele began their illness later whereas patients carrying the 'ss' genotype tended to begin their illness earlier. Differential sampling procedures may influence the proportion of AAO subgroups in a given association study, and therefore these results may explain the conflicting results obtained in studies of the association between the SLC6A4 gene polymorphism and bipolar affective disorder (BPAD). (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.