Association between fast-migrating low-density lipoprotein subfraction as characterized by capillary isotachophoresis and intima-media thickness of carotid artery
Association between fast-migrating low-density lipoprotein subfraction as characterized by capillary isotachophoresis and intima-media thickness of carotid artery
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DOI：
10.1016/j.atherosclerosis.2005.09.005
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发表时间：
2006-07-01
期刊：
影响因子：
5.3
通讯作者：
Saku, Keijiro
中科院分区：
文献类型：
--
作者：
Zhang, Bo;Maeda, Naoyasu;Saku, Keijiro
背景：血浆中存在一种轻度修饰的LDL亚组分，其特征是负电荷增加。这种通过离子交换色谱分离的电负性LDL已被证明是炎症性的，并且其比例在高脂血症和糖尿病患者中增加。本研究探讨了快速（f）-迁移性低密度脂蛋白减法的特点是毛细血管等速电泳（cITP）和颈动脉内膜中层厚度（CA-IMT）之间的关联。方法和结果：本研究包括469名受试者进行了体检。采用高分辨率B超测定CA-IMT。在Beckman P/ACE MDQ系统上通过cITP测量基于电荷的LDL扣除水平。校正年龄后，血清LDL-C水平和cITP flLDL水平升高与CA-INIT升高相关。根据接受者工作特征曲线分析评估，cITP fLDL与CA-INIT之间以及LDL-C与CA-IMT之间的关联程度相似。LDL-C。甘油三酯和残粒样胆固醇水平与cITP fLDL独立相关，LDL-C水平与cITP fLDL相关性最强。cITP fLDL水平与CA-IMT之间的相关性在高LDL-C分层中显著，但在低LDL-C分层中不显著，表明其受到LDL-C水平的影响。结论：cITP fLDL水平与CA-INIT相关，其与LDL-C水平联合是CA-IMT增高的较强指标。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Background: A mildly modified LDL subfraction that is characterized by an increased negative charge exists in plasma. This electronegative LDL separated by ion-exchange chromatography has been shown to be inflammatory and its proportion is increased in patients with hyperlipidemia and diabetes mellitus. The present study examined the association between the level of fast (f)-migrating LDL subtraction characterized by capillary isotachophoresis (cITP) and carotid-artery intima-media thickness (CA-IMT).Methods and results: This study included 469 subjects who underwent a physical examination. CA-IMT was determined by high-resolution B-model ultrasonoraphy. Levels of charge-based LDL subtractions were measured by cITP on a Beckman P/ACE MDQ system. An increased serum LDL-C level and cITP flLDL level were associated with increased CA-INIT after adjusting for age. The extent of the associations between cITP fLDL and CA-INIT and between LDL-C and CA-IMT were similar as assessed by a receiver-operating characteristic curve analysis. LDL-C. triglyceride, and remnant-like particle cholesterol levels were independently correlated with cITP fLDL, and the LDL-C level had the strongest correlation with cITP fLDL. The association between the cITP fLDL level and CA-IMT was significant in the high LDL-C stratum but not in the low stratum, indicating that it is modified by the LDL-C level. The high-LDL-C-high-fLDL group had the highest relative risk for a high CA-IMT among the groups with each combination of LDL-C and cITP fLDL level.Conclusion: The cITP fLDL level was associated with CA-INIT and its combination with the LDL-C level is a stronger indicator for a high CA-IMT. (c) 2005 Elsevier Ireland Ltd. All rights reserved.