Progression of Chronic Kidney Disease in Children With Vesicoureteral Reflux: The North American Pediatric Renal Trials Collaborative Studies Database
Progression of Chronic Kidney Disease in Children With Vesicoureteral Reflux: The North American Pediatric Renal Trials Collaborative Studies Database
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DOI：
10.1016/j.juro.2009.02.085
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发表时间：
2009-10-01
影响因子：
6.6
通讯作者：
Neu, Alicia
中科院分区：
文献类型：
--
作者：
Novak, Thomas E.;Mathews, Ranjiv;Neu, Alicia
Purpose: We describe a cohort of children with chronic kidney disease due to vesicoureteral reflux. We compared the rate of progression to end stage renal disease in those patients to the rate in children with another cause of chronic kidney disease and identified potential risk factors for progression.Materials and Methods: We performed a retrospective cohort study using data from the North American Pediatric Renal Trials and Collaborative Studies Registry. Patients with vesicoureteral reflux as a cause of chronic kidney disease were compared to 2 other diagnostic cohorts. The 3 groups were compared with respect to baseline characteristics and progression to end stage renal disease based on diagnostic category. Multivariate analysis was performed to identify risk factors for progression to end stage renal disease using Cox proportional hazards regression model.Results: Data on 6,981 patients were available for analysis. Patients with vesicoureteral reflux as a cause of chronic kidney disease had a significantly slower rate of progression to end stage renal disease than patients with renal aplasia, hypoplasia or dysplasia and all other causes (log rank p
