Modeling of cell adhesion and deformation mediated by receptor-ligand interactions
Modeling of cell adhesion and deformation mediated by receptor-ligand interactions
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DOI：
10.1007/s10237-015-0694-9
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发表时间：
2016-04-01
影响因子：
3.5
通讯作者：
Nadler, Ben
中科院分区：
文献类型：
--
作者：
Golestaneh, Amirreza F.;Nadler, Ben
本文主要研究受体和配体介导的生物细胞粘附和变形，以完善现有的模型。由于磷脂分子具有足够的面内连续性和流动性，提出了一种各向同性连续流体膜来模拟细胞膜。开发的本构模型占受体的存在下的变形和粘附的细胞膜，通过引入自发的面积扩张的影响。受物理学的启发，基于电荷诱导偶极相互作用，引入了一种非线性受体-配体结合力。受体在膜上的扩散由通过菲克定律的受体-配体相互作用和受体-配体相互作用控制。然后将所开发的模型应用于研究生物细胞的变形和粘附。所提出的模型被用来研究细胞的变形和粘附的材料，绑定，自发的面积扩张和环境属性的作用。
The current work is devoted to studying adhesion and deformation of biological cells mediated by receptors and ligands in order to enhance the existing models. Due to the sufficient in-plane continuity and fluidity of the phospholipid molecules, an isotropic continuum fluid membrane is proposed for modeling the cell membrane. The developed constitutive model accounts for the influence of the presence of receptors on the deformation and adhesion of the cell membrane through the introduction of spontaneous area dilation. Motivated by physics, a nonlinear receptor-ligand binding force is introduced based on charge-induced dipole interaction. Diffusion of the receptors on the membrane is governed by the receptor-ligand interaction via Fick's Law and receptor-ligand interaction. The developed model is then applied to study the deformation and adhesion of a biological cell. The proposed model is used to study the role of the material, binding, spontaneous area dilation and environmental properties on the deformation and adhesion of the cell.