The role of corpus callosum development in functional connectivity and cognitive processing.
The role of corpus callosum development in functional connectivity and cognitive processing.
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DOI：
10.1371/journal.pone.0039804
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Sherr EH
中科院分区：
文献类型：
--
作者：
Hinkley LB;Marco EJ;Findlay AM;Honma S;Jeremy RJ;Strominger Z;Bukshpun P;Wakahiro M;Brown WS;Paul LK;Barkovich AJ;Mukherjee P;Nagarajan SS;Sherr EH
胼胝体被认为在整合信息和调节复杂行为中起着重要作用。在这里，我们表明，缺乏正常的胼胝体发育可能会导致赤字的功能连接，在特定的认知领域的障碍。我们使用α（8-12 Hz）、β（12-30 Hz）和γ（30-55 Hz）频段的脑磁图成像（MEG-I）检查了胼胝体发育不全（AgCC）个体和匹配对照组的静息态功能连接。全局连接（GC）被定义为一个区域与大脑其他部分之间的同步。在AgCC个体中，背外侧前额叶（DLPFC）、后顶叶（PPC）和顶枕叶皮质（PO）的α带GC显著降低。在β或γ带中未观察到GC的显著差异。我们还探讨了这一假设，在AgCC，这一区域的功能连接的减少主要是由一个具体的减少半球间的连接。然而，我们的数据表明，这些区域的连接性降低是由半球间和半球内连接性的错误耦合驱动的。我们还评估了连接程度是否与行为表现相关，重点是已知AgCC个体受损的认知测量。在AgCC参与者中，言语处理速度的神经心理学测量与左内侧和上级颞叶的静息状态功能连接显着相关。DLPFC的连接性与AgCC队列在伦敦塔上的表现密切相关。这些研究结果表明，异常胼胝体发育产生显着的，但选择性的（α带只）休息状态功能连接中断与认知障碍。了解贫困的功能连接和认知之间的关系是确定语言和执行功能障碍的神经机制的关键一步，在常见的神经发育和精神疾病中，胼胝体发育的中断是一致确定的。
The corpus callosum is hypothesized to play a fundamental role in integrating information and mediating complex behaviors. Here, we demonstrate that lack of normal callosal development can lead to deficits in functional connectivity that are related to impairments in specific cognitive domains. We examined resting-state functional connectivity in individuals with agenesis of the corpus callosum (AgCC) and matched controls using magnetoencephalographic imaging (MEG-I) of coherence in the alpha (8–12 Hz), beta (12–30 Hz) and gamma (30–55 Hz) bands. Global connectivity (GC) was defined as synchronization between a region and the rest of the brain. In AgCC individuals, alpha band GC was significantly reduced in the dorsolateral pre-frontal (DLPFC), posterior parietal (PPC) and parieto-occipital cortices (PO). No significant differences in GC were seen in either the beta or gamma bands. We also explored the hypothesis that, in AgCC, this regional reduction in functional connectivity is explained primarily by a specific reduction in interhemispheric connectivity. However, our data suggest that reduced connectivity in these regions is driven by faulty coupling in both inter- and intrahemispheric connectivity. We also assessed whether the degree of connectivity correlated with behavioral performance, focusing on cognitive measures known to be impaired in AgCC individuals. Neuropsychological measures of verbal processing speed were significantly correlated with resting-state functional connectivity of the left medial and superior temporal lobe in AgCC participants. Connectivity of DLPFC correlated strongly with performance on the Tower of London in the AgCC cohort. These findings indicate that the abnormal callosal development produces salient but selective (alpha band only) resting-state functional connectivity disruptions that correlate with cognitive impairment. Understanding the relationship between impoverished functional connectivity and cognition is a key step in identifying the neural mechanisms of language and executive dysfunction in common neurodevelopmental and psychiatric disorders where disruptions of callosal development are consistently identified.