3 MAJOR CYTOGENETIC SUBGROUPS CAN BE IDENTIFIED AMONG CHROMOSOMALLY ABNORMAL SOLITARY LIPOMAS
3 MAJOR CYTOGENETIC SUBGROUPS CAN BE IDENTIFIED AMONG CHROMOSOMALLY ABNORMAL SOLITARY LIPOMAS
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DOI：
10.1007/bf00366238
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发表时间：
1988-07-01
期刊：
影响因子：
5.3
通讯作者：
MITELMAN, F
中科院分区：
文献类型：
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作者：
MANDAHL, N;HEIM, S;MITELMAN, F
我们对35例孤立性脂肪瘤进行了细胞遗传学研究，其中10例是以前报道过的。在本文首次报道的25例肿瘤中，17例检测到克隆性染色体异常。其余8例核型正常，尽管其中两例在约四分之一的细胞中存在非克隆性异常。根据所有35例脂肪瘤的细胞遗传学结果，可将其分为四个主要亚型。这些核型的特点是：(I)含有一个或多个额外环状染色体的超二倍体核型(5例)；(Ii)涉及12q13-14的二倍体核型(13例)，包括t(3；12)(q27-28；q13-14)重排4例；(Iii)除环状染色体或12q13-14重排外，其他异常的亚二倍体或二倍体核型(8例)；(Iv)正常核型(9例)。
We have investigated cytogenetically a total of 35 solitary lipomas, 10 of which have been reported previously. Of the 25 tumours presented herein for the first time, clonal chromosome aberrations were detected in 17. The remaining eight had normal karyotypes, although two of them had non-clonal aberrations in about one quarter of the cells. Based on the cytogenetic findings in all 35 lipomas, four major subgroups can be distinguished. These are characterized by: (I) hyperdiploid karyotypes including one or more supernumerary ring chromosomes (5 cases); (II) diploid karyotypes with mostly balanced rearrangements involving 12q13-14 (13 cases), including the rearrangement t(3;12) (q27-28;q13-14) in 4 cases; (III) hypodiploid or diploid karyotypes with other aberrations than ring chromosomes or rearrangements of 12q13-14 (8 cases); and (IV) normal karyotypes (9 cases).